Mechanosensitivity and Mechanotransduction
This book presents the latest findings in the field of research of mechanosensitivity and mechanotransduction in different cells and tissues. Mechanosensitivity and mechanotransduction of the heart and vascular cells, in the lung, in bone and joint tissue
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Mechanosensitivity in Cells and Tissues Volume 4
Series Editors A. Kamkin Department of Fundamental and Applied Physiology, Russian State Medical University, Ostrovitjanova Str. 1, 117997 Moscow, Russia I. Kiseleva Department of Fundamental and Applied Physiology, Russian State Medical University, Ostrovitjanova Str.1, 117997 Moscow, Russia
For further volumes: http://www.springer.com/series/7878
Andre Kamkin · Irina Kiseleva Editors
Mechanosensitivity and Mechanotransduction
Foreword by Holger Scholz
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Editors Prof. Andre Kamkin Department of Fundamental and Applied Physiology Russian State Medical University Ostrovitjanova Str. 1 117997 Moscow Russia [email protected]
Prof. Irina Kiseleva Department of Fundamental and Applied Physiology Russian State Medical University Ostrovitjanova Str. 1 117997 Moscow Russia [email protected]
Editorial Assistant Dr. Natalia E. Lapina Division of Neurosurgical Research Medical Faculty Mannheim Ruprecht-Karls-University Heidelberg Theodor-Kutzer-Ufer 1-3 D-68167 Mannheim Germany [email protected]
ISBN 978-90-481-9880-1 e-ISBN 978-90-481-9881-8 DOI 10.1007/978-90-481-9881-8 Springer Dordrecht Heidelberg London New York © Springer Science+Business Media B.V. 2011 No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Foreword
“Mechanosensitivity and Mechanotransduction” edited by André Kamkin and Irina Kiseleva describes and discusses the latest research findings in the field of cellular biomechanics. Internationally recognized experts contributed to this comprehensive and visionary work, which represents the accomplishment of a series of four related books. Mechanosensitivity describes the capacity of cells and tissues to perceive mechanical stimuli and translate them into biological signals. As such, mechanosensing and mechanotransduction are fundamental physiological mechanisms allowing cells to react to physical forces. Considering the importance and widespread distribution of mechanosensitive cells in many tissues of the body one can anticipate that a failure of normal mechanosensation may have severe consequences for various disease processes. The book is composed of seven coherent and well-arranged parts covering the multiple aspects of cellular mechanosensation. Part I highlights the role of the cytoskeleton in mechanotransduction. Special attention is given to the function of integrin receptors as mechanotransducers in the myogenic response of blood vessels. Importantly, signalling of integrins in response to enhanced mechanical forces has been implicated in vascular remodelling
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