Metabolites from the Mucus of Volutharpa ampullacea perryi : A Prospective Marine Resource for Bioactive Molecules
- PDF / 3,287,041 Bytes
- 12 Pages / 595.276 x 790.866 pts Page_size
- 28 Downloads / 185 Views
SHORT COMMUNICATION
Metabolites from the Mucus of Volutharpa ampullacea perryi: A Prospective Marine Resource for Bioactive Molecules Tanjun Zhao1 · Simeng Chen2 · Cong Li2 · Senrong Han1 · Yujie Jia2 · Li Liu1 · Yaoyao Zhan1 · Yaqing Chang1 Received: 10 July 2020 / Accepted: 11 November 2020 © Springer Nature B.V. 2020
Abstract The aim of this study is to define compositions and bioactive substances in the mucus derived from the deep-sea snail Volutharpa ampullacea perryi. V. ampullacea perryi, the so-called “false abalone,” is a popular inexpensive seafood along the northern coast of China. The mucus secreted by the pleopod gland of this animal has always been considered a waste product. Here, we used traditional biochemical methods, MTT assays, and metabolomics analyses to determine the composition of the mucus and explore its potential value as a source of bioactive molecules. Crude protein was the major nutrient contained in the mucus of V. ampullacea perryi, and these proteins had anti-cancer potential. In addition, we identified and annotated 332 metabolites in the mucus. Of these, 61.75% had pharmacological functions, 3.61% could be used as cosmetics additives, and 9.04% had nutritional value.
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s12649-020-01308-7) contains supplementary material, which is available to authorized users. Tanjun Zhao, Simeng Chen, Cong Li and Yaqing Chang have contributed equally to this work. Extended author information available on the last page of the article
13
Vol.:(0123456789)
Waste and Biomass Valorization
Graphic Abstract
Keywords Volutharpa ampullacea perryi · Mucus · Overall nutrient composition · Metabolome analysis · Anti-cancer potential
Statement of Novelty
Introduction
This work investigated the anti-cancer effect and metabolite profiles of mucus of Volutharpa ampullacea perryi which is considered as waste.
The deep-sea snail Volutharpa ampullacea perryi (Mollusca, Gastropoda, Prosobranchia, Neogastropoda, Buccinidae, Volutharpa [1, 2]; Fig. 1a, b) is naturally distributed in the soft mud or sandy seafloor of the northern Yellow Sea, China [3]. Because its appearance and pleopod are similar to those of pacific abalone (Haliotis discus, an
Fig. 1 Dorsal (a) and lateral (b) views of Volutharpa ampullacea perryi and its mucus (c)
13
Waste and Biomass Valorization
expensive seafood), V. ampullacea perryi has been called “false abalone” and is considered an inexpensive stand-in for pacific abalone [4]. Although V. ampullacea perryi has been widely used in taxonomic and ecological studies [1, 5–7], little attention has been paid to its commercial value until recently. However, recent studies aiming to increase the commercial value of V. ampullacea perryi have shown that this animal produces many bioactive compounds [4, 8, 9]. For example, Sun et al. isolated a peptide inhibiting angiotension converting enzyme (ACE) from V. ampullacea perryi; this peptide decreases human blood pressure by halting the
Data Loading...
