Metformin
- PDF / 172,399 Bytes
- 1 Pages / 595.245 x 841.846 pts (A4) Page_size
- 68 Downloads / 174 Views
S
1
Zhang QC, et al. Metformin-Associated Lactic Acidosis Presenting Like Acute Mesenteric Ischemia. Journal of Emergency Medicine 57: 720-722, No. 5, Nov 2019. Available from: URL: http://doi.org/10.1016/j.jemermed.2019.04.024 USA 803440676
Drug toxicity and lactic acidosis: case report A 60-year-old woman developed drug toxicity and metformin-associated lactic acidosis (MALA) during treatment with metformin for diabetes mellitus [route, dosage and duration of treatment to reaction onset not stated]. The woman, who had been receiving metformin for diabetes mellitus, presented to emergency department with progressive confusion, nausea, abdominal pain, non-bloody vomiting and diarrhoea for 3 days. Her anamnesis revealed various concurrent conditions and concomitant medications. Initial vital signs showed a BP of 105/47mm Hg, pulse 62 bpm, RR 26 breaths/min and temperature of 32.4°C. Physical examination was notable for diffuse abdominal tenderness and pallor. During neurological examination, she was obtunded and did not follow commands, intermittently moaned and withdrew only to painful stimuli. Examination of the heart and lungs revealed tachycardia with 2+ pulses. Laboratory tests showed haemoglobin of 6 g/dL, blood urea nitrogen 79 mg/dL, creatinine 8.3 mg/dL, lactate 19 mmol/L and anion gap of 32. Serum bicarbonate was undetectable. Venous blood gas testing revealed severe acidosis with a partial pressure of carbon dioxide of
Data Loading...
