Methylphenidate
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Methylphenidate Allergic contact dermatitis in a child: case report A 9-year-old girl developed allergic contact dermatitis during treatment with methylphenidate for attention-deficit and hyperactivity disorder. The girl presented for investigation of a recent pruritic dermatitis, which developed after 8 months of using a methylphenidate patch [dosage not stated]. She developed itchy, burning, red lesions initially on her hip, at the area of patch placement; however, these progressively spread to her legs, arms, abdomen and back. Despite discontinuing the patch, her symptoms continued for 2 months. Histopathological examinations before presentation showed spongiosis consistent with nummular and contact dermatitis. The lesions were not present at the time of examination. Patch testing revealed a positive reaction to a 10% methylphenidate solution, as well as for neat methylphenidate at 0.5%, 1%, 5%, 10% and 20% pet. Nine days after patch placement, the girl presented with a recall reaction. The original pruritic dermatitis had returned to her entire back. She received desonide, and the dermatitis resolved after 5 days. She was advised to avoid methylphenidate patches, and has since remained free of symptoms. Vashi NA, et al. Allergic contact dermatitis caused by methylphenidate. Contact Dermatitis 65: 183-185, No. 3, Sep 2011. Available from: URL: http:// 803060809 dx.doi.org/10.1111/j.1600-0536.2011.01949.x - USA
0114-9954/10/1371-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Reactions 1 Oct 2011 No. 1371
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