Methylphenidate
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Febrile seizure: case report A 12-year-old boy developed febrile seizure while receiving treatment with methylphenidate for attention deficit hyperactivity disorder. He again developed febrile seizure at the age of 16 years during methylphenidate treatment. The boy, who was diagnosed with attention deficit hyperactivity disorder at the age of 10 years, received treatment with atomoxetine, but it was ineffective. Subsequently, the long-acting stimulant of osmotic controlled-release oral delivery system (OROS) methylphenidate 18 mg/day was initiated and was increased to 36 mg/day in due course. Due to irritability and aggressiveness, risperidone was added. Six months after the initiation of risperidone, his irritability and aggressiveness had improved, and risperidone was discontinued. At the age of 12 years, he developed two distinct episodes of generalised seizures. On both occasions, he had a common cold, and his body temperature rose above 38°C. He was diagnosed with febrile seizure by the pediatrician. At age of 15 years, he presented to a clinic and was prescribed OROS-methylphenidate 36 mg/day. At the age of 16 years, he had a common cold, his body temperature rose above 38°C and he experienced a generalised tonic-cyclonic seizure which lasted for 30–40 seconds with a loss of consciousness. He was sent to the emergency room of another hospital. Shortly, his consciousness and spontaneous respiration recovered. His physical and neurological examination was normal, and he was diagnosed with febrile seizure. One week later, he presented to the clinic. He did not have any family history of epilepsy or febrile seizure. He did not have a history drug or alcohol use. He did not have any history of head trauma. His fasting blood glucose levels, renal function test and liver function test were normal. Electroencephalogram a week following the seizure was normal. He did not have any physical or neurological disease. His brain MRI was normal. Thus, a diagnosis of methylphenidate-related febrile seizure was made. Consequently, the boy’s methylphenidate therapy was discontinued. During a 9 month follow-up, his seizures did not recur and his psychotic symptoms were under control. Miyazaki K. Febrile seizure during treatment with methylphenidate. Clinical Neuropsychopharmacology and Therapeutics 11: 51-53, 2020. Available from: URL: http:// 803499240 doi.org/10.5234/cnpt.11.51
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Reactions 5 Sep 2020 No. 1820
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