Microbiome technology empowers the development of traditional Chinese medicine
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Hongtao Liu , Junping Zheng , Hsin-Chih Lai , Baifei Hu , Lin Zhu , 3* 4,5* Elaine Lai-Han Leung & Hong Wei 1
College of Basic Medicine, Hubei University of Chinese Medicine, Wuhan 430065, China; Department of Medical Biotechnology and Laboratory Science, Chang Gung University, Tao-Yuan 33302, China; 3 State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau 2
University of Science and Technology, Macau SAR, China; Central Laboratory, Clinical Medicine Scientific and Technical Innovation Park, Shanghai Tenth People’s Hospital, Tongji University,
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Shanghai 200435, China; State Key Laboratory of Agricultural Microbiology, College of Animal Sciences and Technology, Huazhong Agricultural University, Wuhan 430070, China Received June 08, 2020; accepted July 11, 2020; published online August 7, 2020
Citation:
Liu, H., Zheng, J., Lai, H.C., Hu, B., Zhu, L., Leung, E.L.H., and Wei, H. (2020). Microbiome technology empowers the development of traditional Chinese medicine. Sci China Life Sci 63, https://doi.org/10.1007/s11427-020-1778-7
Application of microbiome technology to traditional Chinese medicine (TCM). Microbiome refers to the integration of composition, genetic information and bio-function of all microbial species under a specific environment. So far, microbiome has been widely introduced to the studies on TCM, which covers the investigation on compositional changes of human microbiome associated with specific TCM syndromes, the molecular mechanisms by which human microbiome affects the syndromes, as well as the interaction of Chinese herbs with human microbiome. According to the difference of microbiome distribution from host organs, the TCM-related microbiome research can be divided into TCM intestinal microbiome, TCM oral microbiome, TCM vaginal microbiome, TCM skin microbiome and TCM respiratory track microbiome. In addition, the subject of TCM microbiome is extended to environmental microbiome related to the Chinese herb cultivation, i.e., TCM rhizosphere microbiome. At present, the significance of TCM intestinal microbiome
*Corresponding authors (Elaine Lai-Han Leung, email: [email protected]; Hong Wei, email: [email protected])
was demonstrated in clinical treatment of TCM formulae or single Chinese herb. For example, two classical formulae, Huangqin decoction and Gegen Qinlian decoction, were proven to improve inflammatory bowel disease, obesity, diabetes and other diseases, the molecular mechanisms of which are closely related to the regulation of intestinal microbiome (Xu et al., 2015; Yang et al., 2017). In the treatment of metabolic diseases, the dietary fiber or water extracts of Chines herbs were discovered to improve the composition of intestinal flora, leading to the weight loss and lipid reduction in both clinical and animal studies (Chang et al., 2015; Zhao et al., 2018). Chinese herb formulae have been proved to be pivo
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