MicroRNA-217 ameliorates inflammatory damage of endothelial cells induced by oxidized LDL by targeting EGR1
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MicroRNA‑217 ameliorates inflammatory damage of endothelial cells induced by oxidized LDL by targeting EGR1 Xuesong Yang1 · Dongna Li2 · Ying‑Zi Qi3 · Wenjing Chen2 · Chuan‑Hua Yang2 · Yue‑Hua Jiang4 Received: 1 June 2020 / Accepted: 24 July 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Oxidized low-density lipoprotein (ox-LDL) modulates gene transcription and expression and induces the development of endothelium inflammation and endothelial dysfunction, in which microRNAs (miRNAs) play a crucial role. However, the mechanism of ox-LDL in inflammatory damage of endothelial cells still remains elusive. Herein, we focused on the effect of hsa-miR-217-5p (miR-217) on endothelial dysfunction induced by ox-LDL by targeting early growth response protein-1 (EGR1). In the present study, 31 upregulated miRNAs and 59 downregulated miRNAs (Fold Change > 2, P value 2 or 3, P value 2, P value 3, P value
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