Minocycline
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Minocycline Eosinophilic myocarditis and cardiogenic shock secondary to DRESS syndrome: case report
A 37-year-old woman developed eosinophilic myocarditis and cardiogenic shock secondary to DRESS syndrome following treatment with minocycline for acne vulgaris. The woman was admitted to the hospital with chills, night sweats, facial swelling and diffuse morbilliform rash approximately 3 weeks after completing a course of minocycline [dosage and route not stated] for the treatment of acne vulgaris. She had been treated with minocycline from 7 May 2015 to 2 June 2015. On admission, peripheral smear revealed transaminitis, eosinophilia and atypical lymphocytes. A transthoracic echocardiogram showed a normal left ventricular function with left ventricular ejection fraction (LVEF) of 68%. Based on the RegiSCAR scoring criteria, she was diagnosed with definite minocycline-induced DRESS syndrome. The woman was initially treated with methylprednisolone followed by prednisone. As a result, her rash resolved, and she was discharged home. After 2 weeks of prednisone therapy, she was readmitted to the hospital with chest tightness and dyspnoea. As a result, she was found to be in cardiogenic shock and required vasopressors and intra-aortic balloon pump (IABP). Transthoracic echocardiogram (TTE) revealed severe global hypokinesis of the left ventricle, LVEF of
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