Minocycline
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Minocycline Scleral pigmentation: case report A man, in his 70s, developed scleral pigmentation during long-term treatment with minocycline for secondary follicular mucinosis and cutaneous mycosis fungoides. The man presented for follow-up eye examination. His medical history was significant for prior radiotherapy, which he had received for choroidal melanoma in the right eye. He also had a secondary follicular mucinosis and cutaneous mycosis fungoides, for which he had been receiving minocycline [minocycline hydrochloride] 100mg twice daily [route not stated] for the past 15 years. At the current presentation, an external eye examination showed newly occurred blue-gray scleral pigmentation across all quadrants of both the eyes, predominantly anterior to the horizontal rectus insertions, with stimulation of melanocytosis. It was determined that the ocular hyperpigmentation was due to therapy with minocycline [outcome not stated]. Author comment: "Minocycline, a lipophilic antibiotic primarily used to treat acne and rosacea, is known to cause ocular pigment deposition in the sclera..." "The patient was treated with minocycline..." "External examination revealed newly detected blue-gray scleral pigmentation in all quadrants of both eyes..." Maloney SM, et al. Long-term Minocycline Therapy With Scleral Pigmentation Simulating Melanocytosis. JAMA Ophthalmology 136: No. 11, Nov 2018. Available from: URL: http://doi.org/10.1001/jamaophthalmol.2018.3088 803433462 USA
0114-9954/19/1779-0001/$14.95 Adis © 2019 Springer Nature Switzerland AG. All rights reserved
Reactions 16 Nov 2019 No. 1779
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