Modeling of Nanotoxicity Molecular Interactions of Nanomaterials wit
This book provides a comprehensive overview of the fundamentals of nanotoxicity modeling and its implications for the development of novel nanomedicines. It lays out the fundamentals of nanotoxicity modeling for an array of nanomaterial systems, ranging f
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Modeling of Nanotoxicity Molecular Interactions of Nanomaterials with Bionanomachines
Modeling of Nanotoxicity
Ruhong Zhou
Modeling of Nanotoxicity Molecular Interactions of Nanomaterials with Bionanomachines
123
Ruhong Zhou Thomas J. Watson Research Center IBM Yorktown Heights, NY USA
ISBN 978-3-319-15381-0 DOI 10.1007/978-3-319-15382-7
ISBN 978-3-319-15382-7
(eBook)
Library of Congress Control Number: 2015947936 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www.springer.com)
To my father Guomei and my mother Hanqing Also to my wife Grace for her everlasting support
Preface
In the past decade alone, we have witnessed enormous advancements in nanoscience and nanotechnology that promise to lead to revolutionary biomedical applications in drug delivery, optical imaging, biosensing, and nanotherapeutics. Accompanying this explosion of innovation, however, there are growing concerns about the biocompatibilities of nanomaterials central to these novel technologies. Many such nanoparticles are known, in specific contexts, to be acutely toxic to humans and detrimental to essential components of our environment. Prior to their broad implementation, it is therefore imperative to assess the deleterious effects these new and exciting technologies might exact on human and environmental health. Given the inherent complexity of nanoparticle–biomolecular interactions, a combined approach featuring state-of-the-art experimental and theoretical techniques is needed to address critical issues involving nanotoxicology at the “bio-nano-med” interface. In parallel with nanotechnological advances, molecular modeling capabilities have rapidly progressed alongside improvements in simulation algorithms and unceasing augmentations to high performance computing resour
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