Molecular Analysis of B Lymphocyte Development and Activation
The B lymphocyte lineage represents an important paradigm for exploring the molecular mechanisms underlying cell fate specification, differentiation and cellular activation. In the past five years, major advances have been achieved in our understanding of
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Editors R.W. Compans, Atlanta/Georgia M.D. Cooper, Birmingham/Alabama T. Honjo, Kyoto · H. Koprowski, Philadelphia/Pennsylvania F. Melchers, Basel · M.B.A. Oldstone, La Jolla/California S. Olsnes, Oslo · M. Potter, Bethesda/Maryland P.K. Vogt, La Jolla/California · H. Wagner, Munich
H. Singh and R. Grosschedl (Ed.)
Molecular Analysis of B Lymphocyte Development and Activation With 28 Figures, 15 in Color
Professor Dr. Harinder Singh Department of Molecular Genetics and Cell Biology Howard Hughes Medical Institute The University of Chicago 5841 S. Maryland Ave. N112 Chicago, IL 60637, USA e-mail: [email protected] Professor Dr. Rudolf Grosschedl Max-Plank-Institute of Immunobiology Department of Cellular and Molecular Immunology Stbeweg 51 79108 Freiburg, Germany e-mail: [email protected] Cover illustration by R. Sciammas (this volume)
Library of Congress Catalog Card Number 72-152360 ISSN 0070-217X ISBN 3-540-23090-4 Springer Berlin Heidelberg New York This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. Springer is a part of Springer Science+Business Media springeronline.com Springer-Verlag Berlin Heidelberg 2005 Printed in Germany The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot quarantee that accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Editor: Dr. Rolf Lange, Heidelberg Desk editor: Anne Clauss, Heidelberg Production editor: Andreas Gsling, Heidelberg Cover design: design & production GmbH, Heidelberg Typesetting: Strtz GmbH, Wrzburg Printed on acid-free paper 27/3150/ag – 5 4 3 2 1 0
Preface
The B lymphocyte lineage represents a leading system for exploring molecular mechanisms that underlie cell fate specification, differentiation and cellular activation. In the past five years major advances have been achieved in the analysis of early B cell development, AID dependent class switch recombination as well as somatic hypermutation and Blimp-1 regulated plasma cell differentiation. Many of these findings and their implications are covered in this volume. Two emergent areas of research that are included in the contributions focus on the pre-BCR and Ikaros-family protein
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