Signal Transduction and the Coordination of B Lymphocyte Development and Function I
Proper development and differentiation of B lymphocytes is es sential to ensure that an organism has the ability to mount an effective humoral immune response against foreign antigens. The immune system must maintain a balance between the deletion of har
- PDF / 36,453,462 Bytes
- 279 Pages / 439.37 x 666.14 pts Page_size
- 59 Downloads / 150 Views
Editors R.W. Compans, Atlanta/Georgia M. Cooper, Birmingham/Alabama J.M. Hogle, Boston/Massachusetts· Y. Ito, Kyoto H. Koprowski, Philadelphia/Pennsylvania· F. Melchers, Basel M. Oldstone, La Jolla/California· S. Olsnes, Oslo M. Potter, Bethesda/Maryland· H. Saedler, Cologne P.K. Vogt, La Jolla/California· H. Wagner, Munich
Springer-Verlag Berlin Heidelberg GmbH
Signal Transduction and the Coordination of B Lymphocyte Development and Function I Transduction of BCR Signals from the Cell Membrane to the Nucleus
Edited by L.B. Justement and K.A. Siminovitch
With 22 Figures and 5 Tables
Springer
LOUIS B. JUSTEMENT, Ph.D. Associate Professor Division of Developmental & Clinical Immunology Department of Microbiology University of Alabama at Birmingham 378 Wallace Tumor Institute Birmingham, AL 35492-3300 USA e-mail: [email protected] Professor KATHERINE A. SIMINOVITCH, M.D. Department of Medicine University of Toronto Mount Sinai Hospital 600 University Ave., Rm. 656A Toronto, Ontario CANADA M5G IX5 e-mail: [email protected] Cover Illustration: Part 1 - Schematic representation of the major signaling pathways activated in response to antigen-mediated cross-linking of the B cell antigen receptor (BCR) complex. Aggregation of the BCR leads to activation of multiple protein tyrosine complexes that inducibly phosphorylate multiple intracellular e!fector proteins. Tyrosine phosphorylation of adaptor proteins promotes the formation of multimolecular complexes, which facilitate the activation and/or localization "/. key signaling proteins. Transcription factor activation is ultimately controlled by Ca + ·dependent (calcineurin and Ca 2 +. calmodulin kinase) as well as calcium independent pathways (Ras and RaeI). Differential transcription factor activation determines the nature of the B cell biological response.
Cover Design: design & production GmbH, Heidelberg ISSN 0070-217X ISBN 978-3-642-63017-0 ISBN 978-3-642-57066-7 (eBook) DOI 10.1007/978-3-642-57066-7 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Verlag. Violations are liable for prosecution under the German Copyright Law.
© Springer·Veriag Berlin Heidelberg 2000 Originally published by Springer-Verlag Berlin Heidelberg New York in 2000 Softcover reprint of the hardcover I st edition 2000 Library of Congress Catalog Card Number 15-12910 The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for g
