Molecular Biology of the SARS-Coronavirus
SARS was the ?rst new plague of the twenty-?rst century. Within months, it spread worldwide from its “birthplace” in Guangdong Province, China, affecting over 8,000 people in 25 countries and territories across ?ve continents. SARS exposed the vulnerabili
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Sunil K. Lal Editor
Molecular Biology of the SARS-Coronavirus
Editor Dr. Sunil K. Lal Virology Group, ICGEB P. O. Box 10504 Aruna Asaf Ali Road New Delhi 110067 India E-mail: [email protected]
ISBN: 978-3-642-03682-8 e-ISBN: 978-3-642-03683-5 DOI 10.1007/978-3-642-03683-5 Springer Heidelberg Dordrecht London New York Library of Congress Control Number: 2009934478 # Springer-Verlag Berlin Heidelberg 2010 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Cover Illustration: 3D model of SARS-CoV, with a wedge cut out of it to reveal the nucleocapsid (see Chap. 3 by Daniel R. Beniac and Timothy F. Booth) Background: HL-CZ cells transfected with SARS-CoV Spike construct and incubated with anti-Spike human monoclonal antibody followed by secondary FITC-labeled anti-human antibody (see Chap. 18 by T. Narasaraju, P.L. Soong, J. ter Meulen, J. Goudsmit and Vincent T.K. Chow) Cover design: WMXDesign GmbH, Heidelberg, Germany Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Foreword
SARS was the first new plague of the twenty-first century. Within months, it spread worldwide from its “birthplace” in Guangdong Province, China, affecting over 8,000 people in 25 countries and territories across five continents. SARS exposed the vulnerability of our modern globalised world to the spread of a new emerging infection. SARS (or a similar new emerging disease) could neither have spread so rapidly nor had such a great global impact even 50 years ago, and arguably, it was itself a product of our global inter-connectedness. Increasing affluence and a demand for wild-game as exotic food led to the development of large trade of live animal and game animal markets where many species of wild and domestic animals were co-housed, providing the ideal opportunities for inter-species transmission of viruses and other microbes. Once such a virus jumped species and attacked humans, the increased human mobility allowed the virus the opportunity for rapid spread. An infected patient from Guangdong who stayed for one day at a hotel in Hong Kong led to the transmission of the disease to 16 other guests who travelled on to seed outbreaks of the disease in Toronto, Singapore, and Vietnam, as well as within H
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