Nucleic Acids and Molecular Biology
Molecular biology has always been a discipline of rapid development. Despite this, we are presently experiencing a period of unprecedented proliferation of information in nucleic acid studies and molecular biology. These areas are intimately interwoven, s
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Professor Dr. FRITZ ECKSTEIN Max-Planck-Institut fur experimentelle Medizin Abteilung Chemie Hermann-Rein-StraBe 3 3400 Gottingen, FRG Dr. DAVID M. J. LILLEY University of Dundee Biochemistry Department Dundee DD1 4HN, UK
Cover illustration by kind permission of B. W. Matthews
ISBN-13: 978-3-642-83386-1 DOl: 10.1007/978-3-642-83384-7
e-ISBN-13: 978-3-642-83384-7
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© Springer-Verlag Berlin Heidelberg 1988 Softcover reprint of the hardcover lst edition 1988 The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Typesetting, printing and binding: Briihlsche Universitatsdruckerei, Giessen 2131/3130-543210
Preface to the Series
From its inception, molecular biology has always been a discipline of rapid development. Despite this·, we are presently experiencing a period of unprecedented proliferation of information in nucleic acid studies and molecular biology. These areas are intimately interwoven, so that each influences the other to their mutual benefit. This rapid growth in information leads to ever-increasing specialization, so that it becomes increasingly difficult for a scientist to keep abreast of developments in all the various aspects of the field, although an upto-date knowledge of the field as a whole is highly desirable. With this background in mind, we have conceived the present series Nucleic Acids and Molecular Biology. It comprises focused review articles by active researchers, who report on the newest developments in their areas of particular interest. The reviews are not intended to be exhaustive, but rather to place the most recent data into context. This format will allow our colleagues to familiarize themselves with new developments in areas outside their own immediate speciality, thus facilitating a more global view of their own work. Moreover, we hope sincerely that this will convey some of the excitement of the interdisciplinary nature of the study of nucleic acids and molecular biology. This series is planned to appear annually. This period will allow us to return to important topics with sufficient frequency to cover new developments as they emerge. Fritz Eckstein David MJ. Lilley
Introduction to Volume 2
The second volume of Nucleic Acids and Molecular Biology c