Nucleic Acids and Molecular Biology
Molecular biology is one of the most rapidly developing and at the same time most exciting disciplines. The key to molecular biology lies in the understanding of nucleic acids - their structure, function, and interaction with proteins. Nucleic Acids and M
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Prof. Dr. FRITZ ECKSTEIN Max-Planck-Institut fUr Experimentelle Medizin Hermann-Rein-Stral3e 3 37075 Gottingen, Germany Prof. Dr. DAVID M. J. LILLEY University of Dundee Biochemistry Department Dundee DDl 4HN United Kingdom
Cover illustration by kind permission of B. W. Matthews
ISBN-13: 978-3-642-78668-6 DOl: 10.1007/978-3-642-78666-2
e-ISBN-13: 978-3-642-78666-2
The Library of Congress has catalogued this serial publication as follows: Library of Congress Catalog Card Number 90-64/8/7 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law.
© Springer-Verlag Berlin Heidelberg 1994 Softcover reprint of the hardcover 1st edition 1994 The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. 39/3130-5 4 3 2 1 0 - Printed on acid-free paper
Preface to the Series
From its inception, molecular biology has always been a discipline of rapid development. Despite this, we are presently experiencing a period of unprecedented proliferation of information in nucleic acid studies and molecular biology. These areas are intimately interwoven, so that each influences the other to their mutual benefit. This rapid growth in information leads to ever-increasing specialization, so that it becomes increasingly difficult for a scientist to keep abreast of developments in all the various aspects of the field, although an up-to-date knowledge of the field as a whole is highly desirable. With this background in mind, we have conceived the present series Nucleic Acids and Molecular Biology. It comprises focused review articles by active researchers, who report on the newest developments in their areas of particular interest. The reviews are not intended to be exhaustive, but rather to place the most recent data into context. This format will allow our colleagues to familiarize themselves with new developments in areas outside their own immediate speciality, thus facilitating a more global view of their own work. Moreover, we hope sincerely that this will convey some of the excitement of the interdisciplinary nature of the study of nucleic acids and molecular biology. This series is planned to appear annually. This period will allow us to return to important topics with sufficient frequency to cover new developments as
