Molecular Classification of Gliomas is Associated with Seizure Control: A Retrospective Analysis
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ORIGINAL PAPER
Molecular Classification of Gliomas is Associated with Seizure Control: A Retrospective Analysis Teresa P. Easwaran5 · Nicola Lancki2 · Mario Henriquez1 · Alexander O. Vortmeyer3 · Nicholas M. Barbaro6 · Denise M. Scholtens2 · Atique U. Ahmed4 · Mahua Dey1 Received: 15 July 2020 / Accepted: 8 October 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Classically, histologic grading of gliomas has been used to predict seizure association, with low-grade gliomas associated with an increased incidence of seizures compared to high-grade gliomas. In 2016, WHO reclassified gliomas based on histology and molecular characteristics. We sought to determine whether molecular classification of gliomas is associated with preoperative seizure presentation and/or post-operative seizure control across multiple glioma subtypes. All gliomas operated at our institution from 2007 to 2017 were identified based on ICD 9 and 10 billing codes and were retrospectively assessed for molecular classification of the IDH1 mutation, and 1p/19q codeletion. Logistic regression models were performed to assess associations of seizures at presentation as well as post-operative seizures with IDH status and the new WHO integrated classification. Our study included 376 patients: 82 IDH mutant and 294 IDH wildtype. The presence of IDH mutation was associated with seizures at presentation [OR 3.135 (1.818–5.404), p
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