Atherogenic index of plasma is associated with the severity of Hidradenitis Suppurativa: a case-control study
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(2020) 19:200
RESEARCH
Open Access
Atherogenic index of plasma is associated with the severity of Hidradenitis Suppurativa: a case-control study José L. Hernández1, Cristina Baldeón2, Ana E. López-Sundh3, J. Gonzalo Ocejo-Vinyals4, Ricardo Blanco5 and Marcos A. González-López6*
Abstract Background: Hidradenitis suppurativa (HS) is a chronic inflammatory disease associated with several comorbidities and vascular risk factors, such as dyslipidemia. The present study aimed to assess the possible associations between the lipid profile and atherogenic indexes and the severity of HS. Methods: This case-control study enrolled 78 HS patients and 62 healthy controls. Classic lipid profile and lipoprotein ratios, including the atherogenic index of plasma (AIP), were evaluated. The severity of HS was measured by the HS Physician Global Assessment (PGA). Results: HS-patients had lower serum total cholesterol and HDL-C levels and higher AIP than the control group. AIP was positively correlated to BMI, waist circumference, systolic and diastolic blood pressure, LDL-C, triglycerides, nonHDL-C, ApoB, HOMA, and hs-CRP and negatively to HDL-C and ApoA1. For the overall lipid profile, only AIP was related to a more severe HS (PGA ≥ 3) after controlling for age, sex, BMI, insulin resistance (IR), active smoking, and statin use (r = 0.268; p = 0.023). Multiple logistic regression adjusted for age, sex, BMI, IR, smoking status and statin use, showed that AIP ≥ 0.11 was significantly associated with the severity of HS (OR, 4.38; CI 95%, 1.09–17.50; p = 0.037). Conclusions: In conclusion, these results showed that AIP is significantly and independently associated with HS severity. Keywords: Hidradenitis suppurativa, Atherogenic indexes, Atherogenic index of plasma, Lipids
Background Hidradenitis suppurativa (HS) is a recurrent chronic inflammatory disease presenting with painful, suppurating lesions affecting the apocrine gland-rich regions of the skin. Prevalence is estimated from 0.05 to 4% across series, and this condition is associated with severe impairment of the quality of life [1]. HS has been related to certain comorbidities and metabolic disorders such as type 2 diabetes mellitus (T2DM) and metabolic syndrome, both * Correspondence: [email protected] 6 Division of Dermatology, Hospital Universitario Marqués de Valdecilla, IDIV AL, University of Cantabria, 39008 Santander, Spain Full list of author information is available at the end of the article
characterized by the common link of insulin resistance (IR) [2–4]. Furthermore, an increased prevalence of vascular risk factors, subclinical atherosclerosis, and a significant risk for major adverse cardiovascular events have also been reported in HS-patients [5–7]. The precise inflammatory mechanism underlying HS is still not fully elucidated, although genetic susceptibility, mechanical stress, obesity, microbiome, and environmental and hormonal factors have been involved [8, 9]. Moreover, in HS-patients, the presence in the affected skin areas and/or in the serum of increased exp
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