Molecular Diagnostics in Dermatology and Dermatopathology
Molecular Diagnostics in Dermatology and Dermatopathology presents the basics of molecular biology and molecular diagnostic methods most commonly used in the clinical laboratory, with an emphasis on the concepts and testing most relevant to dermatological
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Michael J. Murphy Editor
Molecular Diagnostics in Dermatology and Dermatopathology
Editor Michael J. Murphy, MD Division of Dermatopathology Department of Dermatology University of Connecticut Health Center 21 South Rd., Farmington, Connecticut 06030 USA [email protected]
ISBN 978-1-60761-170-7 e-ISBN 978-1-60761-171-4 DOI 10.1007/978-1-60761-171-4 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011921259 © Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
To my parents, Michael and Jacinta, without whose love and sacrifice this undertaking would not have been possible. To Aileen, for her seemingly endless love, patience and support.
Preface
The era of molecular diagnostics in dermatology and dermatopathology is upon us. Advances in genomics are continually redefining our understanding of the pathogenesis and classification of skin disorders. Molecular testing is transforming patient care, facilitating diagnosis, staging, and prognostication of a variety of skin diseases, in addition to guiding the selection of appropriate treatment, monitoring of therapy, and identification of novel therapeutic targets. An understanding of the principles and potential applications of molecular technologies is now essential for any physician practicing in this field. The contents of this book will be of particular interest to dermatologists and dermatopathologists, as well as anatomic pathologists and other physicians/scientists who have an interest in skin disorders, or those who would like to expand their knowledge in this area. The book covers a broad range of cutaneous conditions and specifically emphasizes molecular testing strategies with immediate clinical relevance. I would like to thank all my collaborators in Australia,
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