Molecular Diagnostics in Cancer Patients

This book aims to bring together a broad variety of examples of the role of pharmacogenomics in current drug development, uncovering dynamic concentration-dependent drug responses on biological systems to understand pharmacodynamics responses in human can

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Molecular Diagnostics in Cancer Patients

Kamla Kant Shukla  •  Praveen Sharma Sanjeev Misra Editors

Molecular Diagnostics in Cancer Patients

Editors Kamla Kant Shukla Department of Biochemistry All India Institute of Medical Sciences Jodhpur India

Praveen Sharma Department of Biochemistry All India Institute of Medical Sciences Jodhpur India

Sanjeev Misra Department of Surgical Oncology All India Institute of Medical Sciences Jodhpur India

ISBN 978-981-13-5876-0    ISBN 978-981-13-5877-7 (eBook) https://doi.org/10.1007/978-981-13-5877-7 Library of Congress Control Number: 2019934726 © Springer Nature Singapore Pte Ltd. 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore

Contents

1 Recent Advances in Molecular Diagnostic Approaches for Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Kamla Kant Shukla, Shrimanjunath Sankanagoudar, Barkha Singhal Sanganeria, Puneet Pareek, Jeevan Ram, Sanjeev Misra, and Praveen Sharma 2 Molecular Diagnosis of Gall Bladder Cancer. . . . . . . . . . . . . . . 11 Rajani Rai, Saumyak Gosai, Chinthalapally V. Rao, and Vishal Chandra 3 Molecular Diagnostics for Lung Cancer. . . . . . . . . . . . . . . . . . . 27 Ashok Kumar and Ashwani Tandon 4 Predicting E3 Ubiquitin Ligases as Possible Promising Biomarkers for Brain Tumors. . . . . . . . . . . . . . . . . . 43 Vibhuti Joshi, Arun Upadhyay, Ayeman Amanullah, Ribhav Mishra, and Amit Mishra 5 Molecular Diagnostics in Melanoma: An Update . . . . . . . . . . . 73 A. Srivastava, P. Srivastava, and A. B. Pant 6 Molecular Diagnostics in Breast Cancer. . . . . . . . . . . . . . . . . . . 89 Rajeshwari Sinha and Sanghamitra Pati 7 Molecular Diagnos