Molecular Farming in Plants: Recent Advances and Future Prospects
Since the first recombinant plant-derived pharmaceutical protein (PDP), i.e., human serum albumin, was produced in transgenic tobacco and potato plants in 1990, molecular farming in plants has emerged as a new subject of sciences. The plant system has the
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Aiming Wang • Shengwu Ma Editors
Molecular Farming in Plants: Recent Advances and Future Prospects
Editors Aiming Wang Agriculture and Agri-Food Canada 1391 Sandford Street London, ON N5V 4T3 Canada [email protected]
Shengwu Ma Lawson Health Research Institute/Plantigen Immunology and Transplantation 375 South Street London, ON N6A 4G5 Canada [email protected]
ISBN 978-94-007-2216-3 e-ISBN 978-94-007-2217-0 DOI 10.1007/978-94-007-2217-0 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2011940206 © Springer Science+Business Media B.V. 2012 No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
Molecular farming in plants is an emerging discipline in life sciences. It is also known as molecular pharming or biopharming. Essentially it is using plants including algae to produce pharmaceutical proteins, therapy peptides, vaccine subunits, industrial enzymes and other compounds of interest. The plant system offers practical, biochemical, economic and safety advantages compared with conventional production systems. One successful example is Golden rice that was engineered with the biochemical pathway to biosynthesize beta-carotene, a precursor of pro-vitamin A in the edible parts of rice. This genetically modified rice can be used in areas, particularly in developing countries, where there is a shortage of dietary vitamin A. This book is aimed at reviewing the principles, current advanced methodology, bottleneck problems and futures of molecular farming in plants in anticipation of providing a textbook for students, teachers, and researchers who are interested in molecular farming in plants and plant biotechnology. This book consists of 12 chapters written by international authorities in the field. Overall current status and future prospective of the discipline is discussed in Chap. 1. In the area of therapeutic strategies using stable transgenic plants, cell suspension cultures (Chap. 3), chloroplasts (Chap. 4), transient expression (Chap. 9), and viral vectors (Chap. 10) are extensively reviewed. In addition to plant leaves that have been commonly used for protein production, promising alternatives including plant seed (Chap. 5) and algae (Chap. 6) are also discussed. From the angle of products, Chaps. 7 and 8 particularly address plant-derived vaccines/therapeutic proteins and industrial proteins, respectively. Downstream processing, as an essential part of molecular farming, is reviewed in Chap. 11. In dealing with public concerns about safety, Chap. 12 provides an updated review in this topic. To make this book concise, basic
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