Reviews of Physiology, Biochemistry and Pharmacology

CXC Chemokine Receptors in the Tumor Microenvironment and an Update of Antagonist Development Yang Xun, Hua Yang, Jiekai Li, Fuling Wu, and Fang Liu

Molecular Mechanisms of Fuchs and Congenital Hereditary Endothelial Corneal Dystrophies Darpan

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views of Physiology, Biochemistry and Pharmacology 178

Reviews of Physiology, Biochemistry and Pharmacology Volume 178

Editor-in-Chief Stine Helene Falsig Pedersen, Department of Biology, University of Copenhagen, Copenhagen, Denmark Series Editors Emmanuelle Cordat, Department of Physiology, University of Alberta, Edmonton, Alberta, Canada Diane L. Barber, Department of Cell and Tissue Biology, University of California San Francisco, CA, USA Jens Leipziger, Department of Biomedicine, Aarhus University, Aarhus, Denmark Luis A. Pardo, Max Planck Institute for Experimental Medicine, G€ ottingen, Germany Christian Stock, Department of Gastroenterology, Hannover Medical School, Hannover, Germany Nicole Schmitt, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark Martha E. O’Donnell, Department of Physiology and Membrane Biology, University of California, Davis School of Medicine, Davis, CA, USA

The highly successful Reviews of Physiology, Biochemistry and Pharmacology continue to offer high-quality, in-depth reviews covering the full range of modern physiology, biochemistry and pharmacology. Leading researchers are specially invited to provide a complete understanding of the key topics in these archetypal multidisciplinary fields. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields. 2019 Impact Factor: 4.700, 5-Year Impact Factor: 6.000 2019 Eigenfaktor Score: 0.00067, Article Influence Score: 1.570 More information about this series at http://www.springer.com/series/112

Stine Helene Falsig Pedersen Editor

Reviews of Physiology, Biochemistry and Pharmacology

Editor Stine Helene Falsig Pedersen Department of Biology University of Copenhagen Copenhagen, Denmark

ISSN 0303-4240 ISSN 1617-5786 (electronic) Reviews of Physiology, Biochemistry and Pharmacology ISBN 978-3-030-61506-2 ISBN 978-3-030-61507-9 (eBook) https://doi.org/10.1007/978-3-030-61507-9 © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2020 This work is subject to copyright. All rights are solely and exclusively licensed by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication