Monocyte Subsets Are Differently Associated with Infarct Size, Left Ventricular Function, and the Formation of a Potenti
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ORIGINAL ARTICLE
Monocyte Subsets Are Differently Associated with Infarct Size, Left Ventricular Function, and the Formation of a Potentially Arrhythmogenic Scar in Patients with Acute Myocardial Infarction Xavier Bosch 1,2 & Beatriz Jáuregui 1,2,3 & Neus Villamor 2,4 & Manuel Morales-Ruiz 2,5,6 & José T. Ortiz-Pérez 1,2 & Roger Borràs 1 & Diego Penela 7 & David Soto-Iglesias 1,3 & Rosario J. Perea 8 & Ada Doltra 1 & Susana Prat-González 1 & Wladimiro Jiménez 2,5,6 & Áurea Mira 2,5 & Luis Lasalvia 9 & Antonio Berruezo 3 Received: 21 August 2019 / Accepted: 28 November 2019 # Springer Science+Business Media, LLC, part of Springer Nature 2019
Abstract To investigate the role of classical (CLM, CD14++CD16−), intermediate (INTM, CD14++CD16+), and non-classical (Non-CLM, CD14+CD16++) monocytes in scar formation after ST-elevation myocardial infarction (STEMI), evaluated with cardiac magnetic resonance (CMR). One hundred two patients with a first STEMI had serial blood analyses after 1, 3, and 7 days. A CMR was performed at 7 days and 6 months, depicting scar core (CO), border zone (BZ), and the presence of BZ channels. CLM and INTM levels progressively decreased, correlated with the scar mass, CO, and BZ at 7 days and 6 months (p < 0.05), and inversely with left ventricular ejection fraction (LVEF, p < 0.01). Non-CLM levels gradually increased, correlated with BZ mass and the presence of BZ channels at 7 days and 6 months (p < 0.001).CLM and INTM are associated with infarct size and inversely with LVEF, whereas Non-CLM are associated with BZ mass and the presence of potentially arrhythmogenic substrate. Keywords Monocytes . Myocardial infarction . Left ventricular function . Arrhythmogenic substrate
Introduction Monocytes constitute a critical component of the innate immune response to inflammation. Three subsets have been
described in humans: classical CD14++CD16− monocytes (CLM), intermediate CD14++CD16 + (INTM), and nonclassical CD14+CD16++ (Non-CLM). Monocyte subsets have been shown to contribute to scar formation in specific ways
Associate Editor Joost Sluijter oversaw the review of this article. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s12265-019-09944-8) contains supplementary material, which is available to authorized users. * Antonio Berruezo [email protected] 1
Cardiology Department, Cardiovascular Institute, Hospital Clínic, University of Barcelona, Spain, Carrer de Villarroel, 170, 08036 Barcelona, Spain
2
Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
3
Heart Institute, Teknon Medical Center, Barcelona, Spain
4
Hematopathology Unit, Pathology Department, Hospital Clínic, University of Barcelona, Spain, Barcelona, Spain
5
Biochemistry and Molecular Genetics Department, Hospital Clínic, University of Barcelona, Spain, Barcelona, Spain
6
Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain
7
Cardiology Department, Ospedale Guglielmo d
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