Multiplex Analysis Using cDNA Transcriptomic Profiling
DNA microarrays contain microscopic DNA spots attached to a solid surface. Each spot contains picomolar levels of a specific DNA probe sequence and hybridization to the corresponding gene products can be detected and quantitated through the use of fluores
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Paul C. Guest Editor
Multiplex Biomarker Techniques Methods and Applications
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Multiplex Biomarker Techniques Methods and Applications
Edited by
Paul C. Guest Laboratory of Neuroproteomics, University of Campinas (UNICAMP), Campinas, Brazil
Editor Paul C. Guest Laboratory of Neuroproteomics University of Campinas (UNICAMP) Campinas, Brazil
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-6729-2 ISBN 978-1-4939-6730-8 (eBook) DOI 10.1007/978-1-4939-6730-8 Library of Congress Control Number: 2016958277 © Springer Science+Business Media LLC 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface Due to continuous technical developments and new insights into the high complexity of many diseases, there is an increasing need for multiplex biomarker readouts for improved clinical management and to support the development of new drugs by pharmaceutical companies. The initial rollout of these techniques has led to promising results by helping to read patients as deeply as possible and provide clinicians with information relevant for a personalized medicine approach. This book describes the basic technology platforms being applied in the fields of genomics, proteomics, transcriptomics, metabolomics, and imaging, which are currently the methods of choice in multiplex biomarker research. It also describes the chief medical areas in which the greatest progress has been made and highlights areas where further resources are required. More than 1000 biomarker candidates for various diseases have b
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