Transcriptomic Analysis of Cholestatic Compounds In Vitro
Drug-induced cholestasis is one of the most severe manifestations of drug-induced liver injury. Drug-induced cholestasis is characterized by an accumulation of endogenous metabolites normally excreted in the bile such as bile salts, cholesterol, bilirubin
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Mathieu Vinken Editor
Experimental Cholestasis Research
Methods
in
M o l e c u l a r B i o lo g y
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Experimental Cholestasis Research Edited by
Mathieu Vinken Department of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Brussels, Belgium
Editor Mathieu Vinken Department of In Vitro Toxicology and Dermato-Cosmetology Vrije Universiteit Brussel Brussels, Belgium
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-9419-9 ISBN 978-1-4939-9420-5 (eBook) https://doi.org/10.1007/978-1-4939-9420-5 © Springer Science+Business Media, LLC, part of Springer Nature 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Humana Press imprint is published by the registered company Springer Science+Business Media, LLC, part of Springer Nature. The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface Cholestasis is derived from the Greek words chole meaning bile and stasis indicating halting [1] and denotes any situation of impaired bile secretion with concomitant accumulation of bile acids in the liver or in the systemic circulation. Depending on the location and cause of the obstruction, a distinction can be made between intrahepatic and extrahepatic cholestasis. Intrahepatic cholestasis can be subdivided according to the underlying cause, including drug-induced cholestasis, inherited forms of cholestasis (e.g., progressive familial intrahepatic cholestasis types 1–3), intrahepatic cholestasis of pregnancy, immune-mediated cholestasis (e.g., primary sclerosing cholangitis and primary biliary cholangitis), and cholestasis induced by miscellaneous factors, such as infectious di
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