Multisensory Systems Based on Nafion Membranes Modified by PEDOT for the Determination of Sulfacetamide in Aqueous Solut
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isensory Systems Based on Nafion Membranes Modified by PEDOT for the Determination of Sulfacetamide in Aqueous Solutions and Pharmaceuticals T. S. Titovaa, *, P. A. Yurovaa, b, D. D. Evdokimovac, T. S. Kolganovac, A. V. Parshinac, I. A. Steninaa, O. V. Bobreshovac, and A. B. Yaroslavtseva, b aKurnakov
Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, 119991 Russia b National Research University Higher School of Economics, Moscow, 101000 Russia c Voronezh State University, Voronezh, 394006 Russia *e-mail: [email protected] Received July 25, 2020; revised August 9, 2020; accepted August 11, 2020
Abstract—Composite membrane materials based on Nafion-117 gradient modified by poly(3,4-ethylenedioxythiophene) (PEDOT) are prepared by in situ oxidative polymerization. 0.002 M and 0.01 M solutions of the monomer are used for the synthesis of PEDOT, while the concentration of the oxidant is varied. The equilibrium (water uptake, ion exchange capacity) and transport properties (conductivity, diffusion permeability, coefficient of diffusion) of membranes in the H+- and K+-forms are investigated. The influence of the modification of membranes on the characteristics of cross-sensitive Donnan potential (DP) sensors in the aqueous solutions containing sulfacetamide and an alkali in a wide range of values of pH (5.8–11.2) is studied. The array of cross-sensitive DP-sensors based on membranes with different compositions is used to determine the active substance in “Sul’fatsil natriya” pharmaceuticals from various manufacturers. The relative error of determination is 0.5–3%. Keywords: potentiometric sensors, Donnan potential, cross sensitivity, ion transport, perfluorinated sulfonic acid membranes, PEDOT, hybrid materials, sulfacetamide, pharmaceuticals DOI: 10.1134/S2517751620060098
INTRODUCTION Sulfacetamide (N-[(4-aminophenyl)sulfonyl]acetamide) is a representative of sulfanylamides–synthetic broad-spectrum antibacterial agents as well chemotherapy agents, which can induce allergic reactions and possess carcinogenic activity. Various approaches are applied for their isolation and/or determination. For example, ion exchangers with quaternary amino groups [1, 2] and zeolites [3] are used for the removal of sulfanylamides from aqueous solutions and wastewaters. In some studies, the potential application of carbon nanotubes (CNTs) for the removal of sulfanylamides from natural waters and wastewaters by means of π–π interactions of the sorbate and the sorbent has been shown [4–6]. The formation of complexes between the ions of sulfanylamides and π-electron donating compounds has been confirmed by way of example of the interaction of sulfamethoxazole with naphthalene, phenanthrene, and pyrene in solutions by nuclear magnetic resonance (NMR) [4]. Nanoclusters based on poly(3,4-ethylenedioxythiophene) (PEDOT) were used as the adsorbents for solid-phase extraction of sulfanylamides from objects with a com-
plex composition (e.g., honey) and their subsequent determination by high-performance liquid ch
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