A Electrochemical Sensor for Hyperin Determination in Chinese Medicine Based on Graphene Composites Modified Electrode
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A Electrochemical Sensor for Hyperin Determination in Chinese Medicine Based on Graphene Composites Modified Electrode Huimin Li1 · Yapan Shi1 · Yudong Gao1 Received: 27 March 2020 / Accepted: 6 April 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract A high sensitive voltammetric platform for hyperin detection was developed based on hematite phase iron oxide (α-Fe2O3) doped graphene (GR). The synergistic effects between α-Fe2O3 and GR drastically enhanced the electrocatalytic activity of the resulting materials. The morphology and structure of α-Fe2O3-GR composites were characterized using UV–vis absorption spectra, X-ray diffraction and Transmission Electron Microscopy. By combining the merits of the α-Fe2O3 and GR, a new voltammetric sensor was erected to detect hyperin based on the α-Fe2O3-GR composites. The sensor had good voltammetric response to hyperin, and the linear in the range of 1.0–100 nM. The detection limit of hyperin was found to be 0.5 nM (S/N = 3). Additionally, the designed electrochemical sensor was performed with good selectivity, reproducibility and stability in three real species. Keywords Graphene · Chinese medicine · Electroanalytical · Hyperin
1 Introduction Graphene (GR) and its nanocomposites have attracted worldwide attention due to their biocompatibility, excellent electrical conductivity and large specific surface area [1–4]. Especially the hybrid materials of graphene and metal oxide have been used in various applications [5–7]. While metal oxides can be uniformly loaded on graphene surface, and exhibit good biocompatibility and conductivity [8, 9]. The results show that the perfect combination of graphene and metal oxide has high sensitivity to the measurable target materials. Such as ZnO-GR [10], ZrO2-GR [11], TiO2-GR [12] and F e3O4-GR [13]. α-Fe2O3, as one of the commonly used metal oxides. They have high catalytic activity, adsorption, corrosion resistance, stable chemical properties, biocompatibility and other excellent properties [14, 15]. Among them, α-Fe2O3 shows good conductivity on the surface of Electronic supplementary material The online version of this article (https://doi.org/10.1007/s10904-020-01537-2) contains supplementary material, which is available to authorized users. * Yudong Gao [email protected] 1
Monitoring Department, Henan Bangtai Heli Management Consulting Co., Ltd, Zhengzhou 450001, China
graphene, and has excellent catalytic and enrichment properties in oxidation reaction [16, 17]. Thus, we designed a simple and green method to synthesize α-Fe2O3 GR composite with citric acid as reducing agent, and a sensitive voltammetric sensor for hyperin was constructed. Hyper in, also known as quercetin-3-o-β- d galactopyranoside. It belongs to flavonol glycosides. It is a kind of important natural productincluding,which has many physiological activities, such as anti-in-flammatory, antihypertensive, anti-cancer, liver protection and cholesterol lowering. Some research results show that it has a good effect on c
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