Muscarinic Receptor: From Structure to Animal Models
This volume provides methods for characterization of muscarinic receptor in crystallography studies that advanced our understanding of structural properties and activation mechanism of muscarinic receptors and are cornerstone in molecular modeling and com
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Jaromir Myslivecek Jan Jakubik Editors
Muscarinic Receptor: From Structure to Animal Models
NEUROMETHODS
Series Editor Wolfgang Walz University of Saskatchewan Saskatoon, Canada
For further volumes: http://www.springer.com/series/7657
Muscarinic Receptor: From Structure to Animal Models Edited by
Jaromir Myslivecek Institute of Physiology, Charles University, Prague, Czech Republic
Jan Jakubik Department of Neurochemistry, Acedemy of Sciences of the Czech Republic, Institute of Physiology, Prague, Czech Republic
Editors Jaromir Myslivecek Institute of Physiology Charles University Prague, Czech Republic
Jan Jakubik Department of Neurochemistry Academy of Sciences of the Czech Republic Institute of Physiology Prague, Czech Republic
ISSN 0893-2336 ISSN 1940-6045 (electronic) Neuromethods ISBN 978-1-4939-2857-6 ISBN 978-1-4939-2858-3 (eBook) DOI 10.1007/978-1-4939-2858-3 Library of Congress Control Number: 2015945343 Springer New York Heidelberg Dordrecht London © Springer Science+Business Media New York 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Humana Press is a brand of Springer Springer Science+Business Media LLC New York is part of Springer Science+Business Media (www.springer.com)
Preface Muscarinic receptors are involved in a number of physiological events like cognitive processes, motor coordination, attention, circadian rhythms, food reinforcement, drug addiction, and synaptic plasticity. This book provides methodology for the study of muscarinic receptors at the structural to systemic level. The chapters are primarily intended as a resource for scientists who want to newly establish protocols to study muscarinic receptors without hitches and falling to potential pitfalls. One of such pitfalls is the lack of subtypeselective ligands that makes studies targeted to specific subtype problematic. One of the methodological approaches for subtype identification in tissues and organs is immunohistochemical or Western blot an
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