Muscarinic Receptors
Muscarinic acetylcholine receptors have played a key role in the advancement of knowledge of pharmacology and neurotransmission since the inception of studies in these fields, and the effects of naturally occurring drugs acting on muscarinic receptors wer
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Volume 208
Editor-in-Chief F.B. Hofmann, München Editorial Board J.A. Beavo, Seattle J.E. Barrett, Philadelphia D. Ganten, Berlin P. Geppetti, Florence M.C. Michel, Ingelheim C.P. Page, London W. Rosenthal, Berlin
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Allison D. Fryer Arthur Christopoulos Neil M. Nathanson l
Editors
Muscarinic Receptors
Editors Allison D. Fryer Oregon Health & Science University UHN67 Department of Pulmonary and Critical Care Medicine 3181 SW Sam Jackson Park Road Portland, Oregon 97239 USA [email protected]
Arthur Christopoulos Monash Institute of Pharmaceutical Sciences, Monash University Drug Discovery Biology and Dept. of Pharmacology 399 Royal Parade, Parkville, Victoria, 3052, Australia [email protected]
Neil M. Nathanson University of Washington Department of Pharmacology Room K536A Health Sciences Bldg. Box 357750 Seattle, WA 98195-7750 USA [email protected]
ISSN 0171-2004 e-ISSN 1865-0325 ISBN 978-3-642-23273-2 e-ISBN 978-3-642-23274-9 DOI 10.1007/978-3-642-23274-9 Springer Heidelberg Dordrecht London New York Library of Congress Control Number: 2011943086 # Springer-Verlag Berlin Heidelberg 2012 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
Muscarinic acetylcholine receptors have played a key role in the advancement of knowledge of pharmacology and neurotransmission since the inception of studies in these fields. Indeed, the classical work of Loewi, which led to the identification of acetylcholine as the Vagusstoff released by nerve stimulation, thus showing that synaptic transmission was chemical and not electrical, was based on the actions of neurotransmitter at muscarinic receptors. The physiological actions mediated by muscarinic receptors were known and exploited for both therapeutic and nontherapeutic purposes for hundreds of years before the existence of the receptors themselves was recognized. It is remarkable that the study of muscarinic receptors continues to provide new and surprising insights not just to the cholinergic system, but to the broad areas of neurobiology, cell biology, pharmacology, and therapeutics. Like ot
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