Mycophenolate mofetil
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Leucopenia: 2 case reports Two women developed leucopenia following treatment with mycophenolate mofetil for immunosuppression associated with kidney transplantation [routes not stated]. Patient 1, a 35-year-old woman, was administered mycophenolate mofetil 1.5 g/day following kidney transplantation. Tests performed on postoperative day 75 revealed the following values: WBC count 1800/µL, haemoglobin 9.7 g/dL, neutrophils 675/µL and platelets 158 × 103. Mycophenolate mofetil was replaced with sirolimus; after 14 days, her neutrophil count normalised with a WBC count of 4250/µL and a neutrophil count of 2465/µL. At follow-up, after 15 months, she remained well. Patient 2, a 44-year-old woman, started receiving mycophenolate mofetil 1.5 g/day following kidney transplantation. On postoperative day 88, tests revealed the following values: neutrophils 790/µL, WBC count 1320/µL, haemoglobin 8.0 g/dL and platelets 204 × 103. Mycophenolate mofetil and valganciclovir were withdrawn, and sirolimus was initiated. Her neutrophil count normalised within 7 days; her WBC count was 4120/µL with a neutrophil count of 1755/µL. At follow-up, after 9 months, she remained well. Author comment: "In this experiment, we have reported 2 cases of leukopenia in kidney transplant patients who successfully switched from MMF [mycophenolate mofetil] to sirolimus. Switch from MMF to sirolimus is safe and favorable in MMF-induced leukopenia in renal transplant recipient." Shin BC, et al. Sirolimus: A switch option for mycophenolate mofetil-induced leukopenia in renal transplant recipients. Transplantation Proceedings 45: 2968-2969, No. 8, Oct 2013. Available from: URL: http://dx.doi.org/10.1016/ 803095849 j.transproceed.2013.08.040 - South Korea
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Reactions 23 Nov 2013 No. 1479
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