Mycophenolate mofetil
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Mycophenolate mofetil Lymphoproliferative disorder in the form of diffuse-large-B-cell-lymphoma of the lung: case report
A 76-year-old woman developed lymphoproliferative disorder in the form of diffuse large B-cell lymphoma (DLBCL) of the lung during treatment with mycophenolate mofetil for dermatomyositis. The woman had been diagnosed with anti-PMScl75 antibody-positive dermatomyositis 8 years ago. She had smoked 40 cigarettes/day for 30 years but stopped smoking 15 years ago. She did not have a family history of lung cancer or malignant lymphoma. She had been receiving treatment with prednisolone, azathioprine, tacrolimus, immune-globulin [immunoglobulin] and mycophenolate mofetil 2500 mg/day. She had been receiving mycophenolate mofetil 2500 mg/day for 4 years [route not stated]. At a routine follow-up examination, a chest CT revealed a solitary 18-mm pulmonary nodule in the right middle lobe. She was asymptomatic at that time. Blood tests showed no remarkable changes; the soluble-interleukin-2-receptor (sIL-2R) level was not measured. A transbronchial lung biopsy was performed from the right middle lobe. The histopathologic findings indicated diffuse large B-cell lymphoma [time to reaction onset not stated]. Her Ann Arbor classification was stage IE. An immunodeficiencyassociated lymphoproliferative disorder was suspected. The woman’s therapy with mycophenolate mofetil was stopped. Two months later, the pulmonary nodule in the right middle lobe had decreased to 7mm. Nine months later, the pulmonary nodule had disappeared on chest CT. However, her dermatomyositis had worsened and required increased doses of prednisolone. After additional treatment [details not stated], her dermatomyositis improved. Kobe H, et al. A Case of Mycophenolate Mofetil-induced Diffuse Large B-cell Lymphoma in Which a Solitary Lung Nodule Remitted Spontaneously. Internal Medicine : 2020. Available from: URL: http://doi.org/10.2169/internalmedicine.5027-20 803502081
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Reactions 19 Sep 2020 No. 1822
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