Myocardial Preservation Translational Research and Clinical Applicat
This timely book reveals an integrated approach to myocardial preservation focusing on translational research and clinical applications. Chapters cover both the mechanisms of heart failure in addition to therapeutic considerations, including forms of card
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Myocardial Preservation
Dennis V. Cokkinos Editor
Myocardial Preservation Translational Research and Clinical Application
Editor Dennis V. Cokkinos Heart and Vessel Department Biomedical Research Foundation of the Academy of Athens - Gregory Skalkeas Athens Greece
ISBN 978-3-319-98185-7 ISBN 978-3-319-98186-4 (eBook) https://doi.org/10.1007/978-3-319-98186-4 Library of Congress Control Number: 2018965610 © Springer Nature Switzerland AG 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Dedicated to the Memory of Professor-Academician Gregory D. Skalkeas Man of Unequalled Vision and Unsurpassed Achievement
Foreword
The idea for this book came from the realization, over many years, that the main and determining factor of cardiovascular morbidity and mortality is loss of myocardium. The cardiac muscle, the prime engine of our body, is at a constant danger: before and just after birth from genetically transmitted disease and cardiac defects and at childhood and adolescence from rheumatic fever in developing countries; nonfamilial cardiomyopathy can manifest itself at any time; myocarditis may fell its victim at any age. Hypertension and valve disease nowadays are not left to progress to myocardial loss; however, at the onset of middle age, coronary heart disease begins to take its toll. An initial or recurrent myocardial ischemic insult or infarct sets the stage for cardiac remodeling and its sequelae, heart failure, and death. In old age together with experience and arguable wisdom comes “presbycardia.” Thus, the toil toward cardiac protection is constant and persists throughout a person’s lifetime. “Myocardial preservation” is an all-inclusive term, since it encompasses all
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