n-3 PUFA and caloric restriction diet alters lipidomic profiles in obese men with metabolic syndrome: a preliminary open
- PDF / 953,859 Bytes
- 10 Pages / 595.276 x 790.866 pts Page_size
- 100 Downloads / 134 Views
ORIGINAL CONTRIBUTION
n‑3 PUFA and caloric restriction diet alters lipidomic profiles in obese men with metabolic syndrome: a preliminary open study A. Shabrina1 · T.‑H. Tung1 · N. T. K. Nguyen1 · H.‑C. Lee1 · H.‑T. Wu2 · W. Wang2,3,4 · S.‑Y. Huang1,2,5,6 Received: 27 June 2019 / Accepted: 18 November 2019 © Springer-Verlag GmbH Germany, part of Springer Nature 2019
Abstract Purpose For people with metabolic syndrome (MetS), altering the macronutrient composition of their diets might ameliorate metabolic abnormalities. The common method of clinical assessment only measures total lipid concentrations but ignores the individual species that contribute to these total concentrations. Thus, to predict the amelioration of MetS following caloric restriction (CR) and the intake of fish oil, we used lipidomics to investigate changes in plasma lipids and identify potential lipid metabolites. Methods Lipidomics was performed using ultra-high-performance liquid chromatography–tandem mass spectrometry on plasma samples from a clinical trial conducted over 12 weeks. Subjects were randomized into two groups: CR (n = 12) and CR with fish oil (CRF, n = 9). Anthropometric and clinical parameters were measured and correlated with plasma lipidomics data. Results Compared with baseline, significant differences were observed in body weight, waist circumference, blood pressure and interleukin-6 in both groups, but triglyceride (TG) levels significantly decreased in only the CRF group (all p
Data Loading...
