Modified Nucleic Acids in Biology and Medicine
This volume is comprised of 18 chapters, covering various aspects of DNA modification and RNA modified bases. It also discusses in detail circular RNA, therapeutic oligonucleotides and their different properties. The chemical nature of DNA, RNA, protein a
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Stefan Jurga Volker A. Erdmann Jan Barciszewski Editors
Modified Nucleic Acids in Biology and Medicine
RNA Technologies
More information about this series at http://www.springer.com/series/8619
Stefan Jurga • Volker A. Erdmann • Jan Barciszewski Editors
Modified Nucleic Acids in Biology and Medicine
Editors Stefan Jurga Nanobiomedical Center Adam Mickiewicz University Poznan´ Poland
Volker A. Erdmann (Deceased) Formerly at Institute of Chemistry and Biochemistry Free University Berlin Berlin Germany
Jan Barciszewski Institute of the Bioorganic Chemistry of the Polish Academy of Sciences Poznan´ Poland
ISSN 2197-9731 ISSN 2197-9758 (electronic) RNA Technologies ISBN 978-3-319-34173-6 ISBN 978-3-319-34175-0 (eBook) DOI 10.1007/978-3-319-34175-0 Library of Congress Control Number: 2016944798 © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG Switzerland
Preface
The Power of Modified Nucleic Acids With this volume of the series RNA technologies, we aim to cover various aspects of nucleic acid modifications. This is an interesting issue in the study of macromolecular components of cells. DNA and RNA are key molecules of the cell. The structure, function, and reactivity of DNA and RNA are central to molecular biology and are crucial for the understanding of complex biological processes. For a long time DNA was considered as the most important molecule of all biology and the key of life. However DNA is not the be all and end all of the living cell, but it appears as an important by-product of the RNA evolution. Deoxyribonucleotides as DNA precursors are synthesized by specific enzymatic modification of ribonucleotides in which the 20 -hydroxyl group of the ribose moiety is replaced by 20 -hydrogen with ribonucleotide reductase. One of these DNA bases, thymine, is produced by
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