Natural history of new horizontal meniscal tears in individuals at risk for and with mild to moderate osteoarthritis: da
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Natural history of new horizontal meniscal tears in individuals at risk for and with mild to moderate osteoarthritis: data from osteoarthritis initiative Magdalena Posadzy 1 & Gabby B. Joseph 1 & Charles E. McCulloch 2 & Michael C. Nevitt 2 & John A. Lynch 2 & Nancy E. Lane 3 & Thomas M. Link 1 Received: 26 November 2019 / Revised: 5 April 2020 / Accepted: 15 May 2020 # European Society of Radiology 2020
Abstract Objectives To study the natural history of new horizontal meniscal tears and their association with progression of cartilage degeneration in individuals at risk for or with mild to moderate knee osteoarthritis over 4 years. Methods Individuals who developed a new meniscal tear in the right knee over 2 years were selected from the Osteoarthritis Initiative 3T MRI studies. Knee structural changes were analyzed at the time of tear appearance (baseline), and after 4 years using a modified Whole-Organ Magnetic Resonance Imaging Score (WORMS). Meniscal tears were classified as either horizontal tears or non-horizontal tears. Individuals without a meniscal tear were 1:3 frequency matched according to BMI, gender, race, and age and served as the control group. Linear regression analysis was used to compare cross-sectional and longitudinal changes in cartilage WORMS scores. Results Forty-one subjects developed horizontal tears, including one indiviudal who developed a tear in both menisci, and 34 developed non-horizonal tears. We found that (29/41 (70.7%)) of horizontal and (20/34 (58.8%)) of non-horizonatal tears were stable during follow-up (p = 0.281). Although knees with an incident tear had higher than controls WORMS MAX total knee scores at baseline (coef. = 0.47, p = 0.044, 95% CI = 0.01 to 0.93), there were no significant differences between the horizontal subgroup and knees without tears in overall cartilage scores at baseline and in progression over 4 years of follow-up. Conclusions New horizontal meniscal tears tended to be stable over 4 years and presented no significant differences in progression of cartilage degeneration when compared with knees without tears. Key Points • Most of horizonal meniscal tears were stable over 4 years. • There were no statistically significant differences in overall progression of cartilage degenerative changes between knees with horizonal meniscal tears and control knees without tears • Horizontal tears most often occurred at the posterior horn of the medial meniscus and at the body of the lateral meniscus. Keywords Meniscus . Osteoarthritis . Risk factor
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00330-020-06960-0) contains supplementary material, which is available to authorized users. * Magdalena Posadzy [email protected]; [email protected] 1
Department of Radiology and Biomedical Imaging, University of California San Francisco, 185 Berry Street, Lobby 6, Suite 350, San Francisco, CA 94107, USA
2
Department of Epidemiology and Biostatistics, University of California San Francisc
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