Neisseria macacae bacteremia: report of two cases with a literature review
- PDF / 498,758 Bytes
- 4 Pages / 595.276 x 790.866 pts Page_size
- 58 Downloads / 197 Views
CASE REPORT
Open Access
Neisseria macacae bacteremia: report of two cases with a literature review Yasumasa Yamamoto1* , Norihiko Terada1, Tomoyo Sugiyama1, Hanako Kurai1 and Kiyofumi Ohkusu2
Abstract Background: Neisseria macacae was discovered in the oral cavity of monkeys in 1983. In humans, it has been isolated from the upper respiratory tract of neutropenic patients. However, only two cases of N. macacae bacteremia have been reported in a 65-year-old man with infective endocarditis and a 5-month-old child with fever and petechiae. There are no reports of infections in cancer patients. Here, we present two cases of N. macacae bacteremia in cancer patients. Case presentation: In the first case, a 42-year-old woman who underwent ovarian cancer surgery presented with duodenal invasion associated with multiple lymph node metastasis. N. macacae was isolated from her blood culture and identified using matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS). In the second case, a 69-year-old woman with a long-standing history of esophagogastric junction cancer presented with fever. She had stage IVB cancer with lung, bone, and multiple lymph node metastasis. The last chemotherapy was administered 5 weeks before N. macacae was detected using MALDI-TOF MS and nitrate test negative. In both cases, transthoracic echography showed no vegetation. Antibiotics were administered for 14 and 13 days in the first and second cases, respectively. In both cases, fever alleviated on day 4 of antibiotic administration. Both patients were discharged after their conditions improved. Conclusions: This, to our knowledge, is the first report of N. macacae bacteremia in cancer patients. Both patients, mucosal damage was observed in the upper gastrointestinal tract. Therefore, exclusion diagnosis suggested that bacteremia invasion was caused by mucosal rupture in both cases. Both cases responded well to treatment with βlactam antibiotics and improved after 2 weeks. Modifying the treatment based on the source of the infection may shorten the treatment period. Therefore, further research on N. macacae bacteremia is necessary. Immunocompromised patients such as those with cancer are susceptible to mucosal damage by unusual bacterial species such as N. macacae despite not having contact with monkeys. Keywords: Neisseria macacae, Neisseria species, Bacteremia, Cancer
Background Neisseria macacae is a Neisseria species that was discovered in the oral cavity of monkeys in 1983. In humans, it has been isolated from the upper respiratory tract of neutropenic patients. Human infections of N. macacae are extremely rare. We found only two previous cases of * Correspondence: [email protected] 1 Division of Infectious Diseases, Shizuoka Cancer Center Hospital, 1007 Shimonagakubo, Sunto-gun, Shizuoka, Nagaizumi 411-8777, Japan Full list of author information is available at the end of the article
N. macacae bacteremia in humans. Previously reported cases included a 65-year-old man with infective endocarditis an
Data Loading...
