Oncocytic variant, a novel subtype of chromophobe renal cell carcinoma: a report of two cases and a literature review
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CASE REPORT
Oncocytic variant, a novel subtype of chromophobe renal cell carcinoma: a report of two cases and a literature review Takashi Karashima1 · Naoto Kuroda2 · Takahiro Taguchi3 · Hideo Fukuhara1 · Takahira Kuno1 · Kenji Tamura1 · Makoto Hiroi4 · Keiji Inoue1 · Tadanori Yamaguchi5 Received: 26 August 2020 / Accepted: 14 November 2020 © The Author(s) 2020
Abstract A novel variant of chromophobe renal cell carcinoma showing an oncocytic phenotype is proposed. Two new cases of this rare entity are presented and discussed along with six previous cases from our colleagues. A 76-year-old man and a 78-year-old man had a 3.4-cm and a 3.2-cm-diameter renal mass, respectively. On histopathological examination of surgical specimens, uniform eosinophilic cuboidal cells without a perinuclear halo growing in a tubular pattern were seen, and differential diagnosis from oncocytoma was necessary. Immunohistochemical staining for cytokeratin 7 and E-cadherin showed diffusely positive patterns in both, as in the previous reports. Although monosomy of chromosomes 7, 10, 13, and 17 was commonly observed in the previous reports, gains of chromosome 19 were observed in the two present cases. Immunohistochemical and cytogenetic approaches lead to exclusion of oncocytoma and the diagnosis of an oncocytic variant of chromophobe renal cell carcinoma. Keywords Chromophobe renal cell carcinoma · Oncocytoma · Oncocytic variant Abbreviations CD10 Cluster of differentiation 10 CD82 Cluster of differentiation 82 CGH Comparative genomic hybridization ChRCC Chromophobe renal cell carcinoma CK7 Cytokeratin 7 E-Cad E-cadherin EpCAM Epithelial cell adhesion molecule FISH Fluorescence in situ hybridization MIA Mitochondrial antigen RCC Renal cell carcinoma TFE3 Transcription factor E3 * Takashi Karashima karasima@kochi‑u.ac.jp 1
Department of Urology, Kochi Medical School, Kochi University, Kohasu, Oko, Nankoku, Kochi 783‑8505, Japan
2
Department of Diagnostic Pathology, Kochi Red Cross Hospital, Kochi 780‑0062, Japan
3
Human Health and Medical Science, Faculty of Medicine, Kochi University, Nankoku 783‑8505, Japan
4
Laboratory of Diagnostic Pathology, Kochi Medical School Hospital, Nankoku 783‑8505, Japan
5
Department of Cytopathology, Ayabe City Hospital, Ayabe 623‑0011, Japan
Introduction Chromophobe renal cell carcinoma (ChRCC) is a rare variety of kidney neoplasm that accounts for approximately 5% of renal cell carcinomas (RCCs). ChRCC was first described in 1985 by Thoenes et al., who reported 12 cases of renal tumors consisting of chromophobe cells showing slightly opaque or finely reticular cytoplasm on hematoxylin and eosin staining [1]. Most ChRCCs are diagnosed at an earlier stage and show a better prognosis than conventional clear cell RCC. ChRCC is classified into three variants. The classic type, with more than 80% pale cells, is associated with necrosis and sarcomatoid changes with high growth and metastases. The eosinophilic variant, with more than 80% eosinophilic cells, shares certain charact
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