Neuroblastoma
Neuroblastoma is a medical enigma. As a childhood neoplasm arising from neural crest cells, it is characterized by diverse clinical behaviors ranging from spontaneous remission to rapid tumor progression and death. Although clinical outcome can be predict
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Nai-Kong V. Cheung Susan L. Cohn (Eds.)
Neuroblastoma With 51 Figures and 48 Tables
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Library of Congress Control Number 2004113134 ISBN-10 3-540-40841-X Springer Berlin Heidelberg NewYork ISBN-13 978-3-540-40841-3 Springer Berlin Heidelberg NewYork ISSN 1613-5318
Nai-Kong V. Cheung, MD, PhD
(e-mail: [email protected]) Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA Susan L. Cohn, MD (e-mail: [email protected]) Department of Pediatrics and the Comprehensive Robert H. Lurie Cancer Center, Northwestern University, Feinberg School of Medicine, Children’s Memorial Hospital 2300 Children’s Plaza, Chicago, IL 60614, USA
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Preface
The rapid advances in our understanding of the biology and treatment of neuroblastoma make it difficult to keep up to date. The clinical facets of neuroblastoma are endlessly fascinating. Its “natural history” overtly displays the difference between cancer and a truly extraordinary non-malignant proliferative disease. An interesting and potentially promising research emphasis is to unravel the difference between the “good” and “bad” forms of the disease. Our interest in neuroblastoma was kindled by clinical observations going back many decades. For example, is it likely that neuroblastoma “metastasizes” from one adrenal to the other and to the posterior mediastinum, or that malignant secondary deposits in these three unlikely sites will disappear spontaneousl
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