Mitochondrial Dysfunction in Neurodegenerative Disorders
This second edition brings together up-to-date contributions from leaders in the field internationally on the various ways in which mitochondrial dysfunction contributes to the pathogenesis of neurodegenerative diseases, including Parkinson’s disease, Alz
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Mitochondrial Dysfunction in Neurodegenerative Disorders
Amy K. Reeve • Eve M. Simcox Michael R. Duchen • Doug M. Turnbull Editors
Mitochondrial Dysfunction in Neurodegenerative Disorders Second Edition
Editors Amy K. Reeve Newcastle University Medical School Wellcome Trust Centre for Mitochondrial Research Newcastle upon Tyne UK Eve M. Simcox Newcastle University Medical School Wellcome Trust Centre for Mitochondrial Research Newcastle upon Tyne UK
Michael R. Duchen Cell and Developmental Biology University College London London UK Doug M. Turnbull Newcastle University Medical School Wellcome Trust Centre for Mitochondrial Research Newcastle upon Tyne UK
ISBN 978-3-319-28635-8 ISBN 978-3-319-28637-2 DOI 10.1007/978-3-319-28637-2
(eBook)
Library of Congress Control Number: 2016941596 © Springer International Publishing 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG Switzerland
Preface
The loss of neurons at any stage of life is a catastrophic event. These post-mitotic cells lack the ability to regenerate and as such their loss is an unthinkable finality. The most widely recognised diseases in which this cell loss occurs are related to advancing age, for example, Parkinson’s disease and Alzheimer’s disease, but there are several diseases which may occur at a much younger age, for example, multiple sclerosis and motor neuron disease. The expansion in research into roles for mitochondria in the pathogenesis of these diseases has been great in the 3 years since the first edition of Mitochondrial Dysfunction in Neurodegenerative Disease, and now a significant body of work is dedicated to unearthing new therapies and drugs to protect neurons against such dysfunction and loss. With ever-increasing numbers of papers being published in the field of mitochondria and neurodegenerative disease, we wanted to bring together
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