Intracellular Traffic and Neurodegenerative Disorders
This book explores the role of sub-cellular trafficking in the pathogenesis, treatment and prevention of neurodegenerative diseases. Recent findings point to faulty trafficking as contributing to the dysfunction and degeneration of neurons and neural circ
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P. H. St.George-Hyslop W. C. Mobley · Y. Christen (Eds.)
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POUR LA RECHERCHE
THERAPEUTIQUE
Intracellular Traffic and Neurodegenerative Disorders
RESEARCH AND PERSPECTIVES IN ALZHEIMER’S DISEASE
Peter H. St. George-Hyslop Yves Christen
•
William C. Mobley
Editors
Intracellular Traffic and Neurodegenerative Disorders
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Editors Dr. Peter H. St. George-Hyslop Department of Laboratory Medicine and Pathobiology University of Toronto Tranz Neuroscience Bldg. Toronto ON M5S 3H2 Canada [email protected]
Dr. William C. Mobley Department of Neurology Standford University School of Medicine Standford CA 94305-5316 USA [email protected]
Dr. Yves Christen Fondation IPSEN Pour la Recherche Thérapeutique 65, quai Georges Gorse 92650 Boulogne Billancourt Cedex - France [email protected]
ISSN 0945-6066 ISBN 978-3-540-87940-4
e-ISBN 978-3-540-87941-1
Library of Congress Control Number: 2008936139 c 2009 Springer-Verlag Berlin Heidelberg This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Printed on acid-free paper springer.com
Foreword
Neurodegenerative disorders are common and devastating. Rationally, the most effective treatments will target pathogenetic mechanisms. While alternative approaches, based on alleviating the symptoms of patients with Alzheimer disease, Parkinson disease, Huntington disease, prion disorders or amyotrophic lateral sclerosis, can be expected to reduce suffering, studies of pathogenesis of these agerelated disorders will be most important for enabling early diagnosis and the creation of preventative and curative treatments. It is in this context that a recent IPSEN meeting (The 23rd Colloque M´edecine et Recherche, April 28, 2008) focused on a role for disruption of intracellular trafficking in neurodegenerative disorders. The meeting captured emerging insights into pathogenesis from disrupted trafficking and processing of proteins implicated in age-related degeneration. Protein folding, trafficking and signaling were the principal topics covered at the meeting. Importantly, the presenters pointed to the importantly intersection of these themes. While the proteolytic processing of APP into its toxic product, the Aβ peptide,
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