Neurological manifestations of COVID-19: a systematic review and meta-analysis of proportions
- PDF / 1,291,346 Bytes
- 34 Pages / 595.276 x 790.866 pts Page_size
- 30 Downloads / 176 Views
COVID-19
Neurological manifestations of COVID-19: a systematic review and meta-analysis of proportions T. T. Favas 1 & Priya Dev 1 & Rameshwar Nath Chaurasia 1 & Kamlesh Chakravarty 2 & Rahul Mishra 3 & Deepika Joshi 1 & Vijay Nath Mishra 1 & Anand Kumar 1 & Varun Kumar Singh 1 & Manoj Pandey 4 & Abhishek Pathak 1 Received: 9 August 2020 / Accepted: 5 October 2020 # Fondazione Società Italiana di Neurologia 2020
Abstract Background Coronaviruses mainly affect the respiratory system; however, there are reports of SARS-CoV and MERS-CoV causing neurological manifestations. We aimed at discussing the various neurological manifestations of SARS-CoV-2 infection and to estimate the prevalence of each of them. Methods We searched the following electronic databases; PubMed, MEDLINE, Scopus, EMBASE, Google Scholar, EBSCO, Web of Science, Cochrane Library, WHO database, and ClinicalTrials.gov. Relevant MeSH terms for COVID-19 and neurological manifestations were used. Randomized controlled trials, non-randomized controlled trials, case-control studies, cohort studies, cross-sectional studies, case series, and case reports were included in the study. To estimate the overall proportion of each neurological manifestations, the study employed meta-analysis of proportions using a random-effects model. Results Pooled prevalence of each neurological manifestations are, smell disturbances (35.8%; 95% CI 21.4–50.2), taste disturbances (38.5%; 95%CI 24.0–53.0), myalgia (19.3%; 95% CI 15.1–23.6), headache (14.7%; 95% CI 10.4–18.9), dizziness (6.1%; 95% CI 3.1–9.2), and syncope (1.8%; 95% CI 0.9–4.6). Pooled prevalence of acute cerebrovascular disease was (2.3%; 95%CI 1.0–3.6), of which majority were ischaemic stroke (2.1%; 95% CI 0.9–3.3), followed by haemorrhagic stroke (0.4%; 95% CI 0.2–0.6), and cerebral venous thrombosis (0.3%; 95% CI 0.1–0.6). Conclusions Neurological symptoms are common in SARS-CoV-2 infection, and from the large number of cases reported from all over the world daily, the prevalence of neurological features might increase again. Identifying some neurological manifestations like smell and taste disturbances can be used to screen patients with COVID-19 so that early identification and isolation is possible. Keywords COVID-19 neurological manifestations . Acute cerebrovascular disease . SARS-CoV-2 infection . Meningoencephalitis . Guillain-Barré syndrome . Smell and taste disturbances
Background Coronaviruses are enveloped, positive-stranded RNA viruses that mainly cause respiratory and gastrointestinal tract infections
* Abhishek Pathak [email protected] 1
Department of Neurology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
2
Department of Neurology, PGIMER, Chandigarh, India
3
Department of Statistics, Institute of science, Banaras Hindu University, Varanasi, India
4
Department of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
[1]. They are divided into four genera: alpha, beta, delta, and gamma. Alphacoronavirus and b
Data Loading...
