Worldwide management of donors after neurological death: a systematic review and narrative synthesis of guidelines
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REVIEW ARTICLE/BRIEF REVIEW
Worldwide management of donors after neurological death: a systematic review and narrative synthesis of guidelines Prise en charge des donneurs apre`s un de´ce`s neurologique dans le monde : revue syste´matique et synthe`se narrative des lignes directrices Anne Julie Frenette, PharmD, PhD . David Williamson, BPharm, PhD . Matthew-John Weiss, MD . Bram Rochwerg, MD, MSc, FRCPC . Ian Ball, MD, MSc . Dave Brindamour, BPharm, MSc . Karim Serri, MD . Frederick D’Aragon, MD, MSc . Maureen O. Meade, MD, MSc . Emmanuel Charbonney, MD, PhD Received: 23 April 2020 / Revised: 2 July 2020 / Accepted: 2 July 2020 Canadian Anesthesiologists’ Society 2020
Abstract Objective The objectives of this study were to systematically identify and describe guidelines for the care of neurologically deceased donors and to evaluate their methodological quality, with the aim of informing and supporting the new Canadian guidelines for the management of organ donors. Methodology Following a systematic search, we included any document endorsed by an organ donation
organization, a professional society, or a government, that aims to direct the medical management of adult, neurologically deceased, multi-organ donors. We extracted recommendations pertaining to six domains: the autonomic storm, hemodynamic instability, hormone supplementation, ventilation, blood product transfusions, and general intensive care unit (ICU) care. Methodological quality of the guidelines was assessed by the validated AGREE-II tool.
A. J. Frenette, PharmD, PhD (&) Department of Pharmacy, Hoˆpital du Sacre´-Cœur de Montre´al, Montreal, QC, Canada e-mail: [email protected]
M.-J. Weiss, MD Population Health and Optimal Health Practices Research Unit, Trauma-Emergency-Critical Care Medicine, CHU de Que´bec, Universite´ Laval Research Center, Quebec, QC, Canada
Faculte´ de Pharmacie, Universite´ de Montre´al, Montreal, QC, Canada
Pediatrics Department, Intensive Care Division, Faculte´ de Me´decine, Universite´ Laval, Quebec, QC, Canada
Faculte´ de Me´decine, Universite´ de Montre´al, Montreal, QC, Canada
Transplant Que´bec, Montreal, QC, Canada
Centre de recherche CIUSSSS du Nord de L’Ile, Hoˆpital du Sacre´-Coeur de Montre´al, 5400 Gouin Ouest, Montre´al, QC H4J 1C5, Canada D. Williamson, BPharm, PhD Department of Pharmacy, Hoˆpital du Sacre´-Cœur de Montre´al, Montreal, QC, Canada Faculte´ de Pharmacie, Universite´ de Montre´al, Montreal, QC, Canada Centre de recherche CIUSSSS du Nord de L’Ile, Hoˆpital du Sacre´-Coeur de Montre´al, 5400 Gouin Ouest, Montre´al, QC H4J 1C5, Canada
B. Rochwerg, MD, MSc, FRCPC Department of Medicine, McMaster University, Hamilton, ON, Canada Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada I. Ball, MD, MSc Department of Medicine, Western University, London, ON, Canada D. Brindamour, BPharm, MSc Department of Pharmacy, Hoˆpital du Sacre´-Cœur de Montre´al, Montreal, QC, Canada
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Main findings This review includ
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