Neuroprotective Effect Of Peptide Fractions from Chia ( Salvia hispanica ) on H 2 O 2 -Induced Oxidative Stress-Mediated

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Neuroprotective Effect Of Peptide Fractions from Chia (Salvia hispanica) on ­H2O2‑Induced Oxidative Stress‑Mediated Neuronal Damage on N1E‑115 Cell Line Edwin E. Martínez Leo1 · Maira R. Segura Campos1  Received: 28 April 2020 / Revised: 20 June 2020 / Accepted: 2 July 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020

Abstract Neurodegenerative diseases (ND) affect around a billion people worldwide. Oxidative stress plays a critical role in the activation of neuronal death mechanisms, implicated in the ND etiology. In the present research, the neuroprotective effect of the S. hispanica protein derivatives is evaluated, on neuronal cells N1E-115, after the damage induction with ­H2O2. From the protein-rich fraction of S. hispanica, three peptide fractions were obtained (3–5, 1–3 y

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