New Diagnostic Methods in Oncology and Hematology
This book describes the latest methods in oncological and hematological diagnostics, including immunological, molecular genetic and cytogenetic assays. All methods are described in their different variations and compared in terms of cost and effectiveness
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Springer-Verlag Berlin Heidelberg GmbH
Dieter Huhn (Ed.)
New Diagnostic Methods in Oncology and Hematology With Contributions by R. Blasczyk, C. Fonatsch, D. Huhn, O. Meyer, S. Nagel, A. Neubauer, J. Oertel, A. Salama, S. Serke, B. Streubel, and C. Thiede
With 82 Figures
IP
Springer
Professor Dr. med. D I E T E R H U H N
Universitätsklinikum Charite Medizinische Fakultät der Humboldt-Universität zu Berlin Augustenburger Platz 1 D-13353 Berlin Germany
ISBN
978-3-642-63739-1
Library of Congress Cataloging-in-Publication Data New diagnostic methods in oncology and hematology / D. Huhn (ed.). p. cm. Includes bibliographical references and index.
ISBN 978-3-642-63739-1 ISBN 978-3-642-58803-7 (eBook) DOI 10.1007/978-3-642-58803-7
1. Blood-Diseases-Diagnosis. 2. Cancer—Diagnosis. 3. Diagnosis, Molecular. 4. Immunohematology. 5. Human chromosome abnormalities—Diagnosis. I. Huhn, Dieter. [DNLM: 1. Neoplasms—diagnosis. 2. Hematologic Neoplasms-diagnosis. 3. Immunohistochemistry. 4. Molecular Biology-methods. QZ 241 N5288 1998] RB45.N47 1998 616.1'5075--dc21 DNLM/DLC This work is subject to copyright. All rights reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9,1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. Springer-Verlag Berlin Heidelberg 1998 Originally published by Springer-Verlag Berlin Heidelberg New York in 1998 The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Typesetting: Data conversion by Springer-Verlag, Heidelberg Cover Design: Design 8c Production, Heidelberg SPIN 10565866 09/3137 - 5 4 3 2 1 0 - Printed on acid-free paper
Preface
Since Paul Ehrlich introduced aniline dyes to the staining procedures for hematological smears in the second half of the last century, morphological techniques have been at the center of developments-in clinical diagnostics and research in hematology for about 100 years. The results of morphologic and cytochemical methods in the diagnostics of hematological disease have been compiled in several excellent monographs. During the 1960s our understanding of cellular structure and function was consolidated by the introduction of electron microscopy. With few exceptions (e.g. dyserythropoietic anemia), knowledge of the ultrastructure of the cells made no essential contributions to practical clinical diagnostics. During the past 25 years our understanding of the pathogenesis of hematological and oncological disease as well as
