Nonprimate Lentiviral Vectors
Advances in the nascent field of gene therapy have created a demand for gene transfer vehicles that are capable of safely and stably delivering genes to both dividing and nondividing cells. Retroviral vectors, by virtue of their ability to permanently int
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Editors R.W. Compans, Atlanta/Georgia M . Cooper, Birmingham/Alabama • Y . Ito, Kyoto H . Koprowski, Philadelphia/Pennsylvania • F. Melchers, Basel M . Oldstone, La Jolla/California • S. Olsnes, Oslo M . Potter, Bethesda/Maryland P.K. Vogt, La Jolla/California • H . Wagner, Munich
Springer-Verlag Berlin Heidelberg GmbH
Lentiviral Vectors Edited by Didier Trono
With 32 Figures and 8 Tables
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Springer
Professor Dr. DIDIER T R O N O
Department of Genetics and Microbiology Faculty of Medicine University of Geneva C M U ; 1 rue Michel-Servet 1211 Geneva 4 Switzerland e-mail: [email protected]
Cover Illustration: Cure in a lentiviral package (symbolic representation) (D. Trono and M . Locke) ISSN 0070-217X ISBN 978-3-642-62667-8 ISBN 978-3-642-56114-6 (eBook) DOI 10.1007/978-3-642-56114-6 This work is subject to copyright. A l l rights are reserved, whether the whole or part of the material is concerned, specifically the rights o f translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage i n data banks. Duplication of this publication or parts thereof is permitted only under the provisions o f the German Copyright L a w o f September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright L a w . http://www.springer.de © Springer-Verlag Berlin Heidelberg 2002 Originally published by Springer-Verlag Berlin Heidelberg New York in 2002 Softcover reprint of the hardcover 1st edition 2002 Library o f Congress Catalog Card Number 15-12910 The use o f general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence o f a speciic statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy o f any information about dosage and application contained i n this book. In every individual case the user must check such information by consulting other relevant literature. Cover Design: design & production GmbH, Heidelberg Typesetting: Scientific Publishing Services (P) L t d , Madras Printed on acid-free paper S P I N : 10778540 27/3020 - 5 4 3 2 1 0
Preface
``Felix qui potuit rerum cognoscere causas (Virgil) (Happy the one who could penetrate the secret causes of things)''
In the 20 years of war against HIV, the cause of one of the most dreadful health disasters of all times, a few battles have been won: the virus's major modes of transmission were quickly identi®ed, a blood test was created, and highly active antiviral therapies were developed which have changed the face of the disease in wealthy parts of the world. The ®ght against HIV will not abate short of a vaccine and of aordable, easy to take and nontoxic therapies. Yet AIDS research has, in addition, provided insights into many basic biological and medical questions. One of its unexpe
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