The Vasohibin Family: Novel Regulators of Angiogenesis
A number of endogenous regulators of angiogenesis have been found in the body. We isolated vasohibin-1 (VASH1) as a negative feedback regulator of angiogenesis produced by endothelial cells, and then VASH2 as a homologue of VASH1. We further explored that
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genesis and Vascularisation Cellular and Molecular Mechanisms in Health and Diseases
Angiogenesis and Vascularisation
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Jo´zef Dulak • Alicja Jo´zkowicz • Agnieszka Łoboda Editors
Angiogenesis and Vascularisation Cellular and Molecular Mechanisms in Health and Diseases
Editors Jo´zef Dulak Alicja Jo´zkowicz Agnieszka Łoboda Department of Medical Biotechnology Faculty of Biochemistry, Biophysics and Biotechnology Jagiellonian University Krako´w Poland
ISBN 978-3-7091-1427-8 ISBN 978-3-7091-1428-5 (eBook) DOI 10.1007/978-3-7091-1428-5 Springer Wien Heidelberg New York Dordrecht London Library of Congress Control Number: 2014931375 # Springer-Verlag Wien 2013 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
There is no vertebrate life without blood vessels and blood circulation. Therefore, formation of blood vessels is strictly connected with the continuous well-being of human during development and adult life, and finally, disturbed—impaired or exaggerated—angiogenesis leads to development or aggravation of disease. Understanding the mechanisms of physiological and pathological vascularization is thus really a matter of life and death. The discoveries of the last 25 years have identified plethora of angiogenic mediators including transcription factor
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