Nuclear Reprogramming and Stem Cells
Research into the field of stem cell biology has developed exponentially over recent years, and is beginning to offer significant promise for unravelling the molecular basis of a multitude of disease states. Importantly, in addition to offering the opport
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Series Editor Kursad Turksen, Ph.D. [email protected]
For further volumes: http://www.springer.com/series/7896
Justin Ainscough Takashi Tada
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Shinya Yamanaka
Editors
Nuclear Reprogramming and Stem Cells
Editors Justin Ainscough Division of Cardiovascular and Neuronal Remodelling Leeds Institute of Genetics Health and Therapeutics University of Leeds Leeds, UK [email protected]
Shinya Yamanaka Centre for iPS Cell Research and Application (CiRA) Kyoto University Kyoto, Japan [email protected]
Takashi Tada Stem Cell Engineering Institute for Frontier Medical Sciences Kyoto University Kyoto, Japan [email protected]
Title page image shows expression of a DNA replication protein in mouse embryonic stem cells, courtesy of Sumia Bageghni and Erin Greaves, Leeds, UK. ISBN 978-1-61779-224-3 e-ISBN 978-1-61779-225-0 DOI 10.1007/978-1-61779-225-0 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011934356 © Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
Preface
Rarely has a field of research generated such intense interest and division between individuals as the field of stem cell biology. This has become, without rival, the most awe inspiring area of biological research in recent times, and can only increase in importance as the potential impact on human health is realised. The field is evolving on a weekly basis with dramatic new discoveries bringing the possibility of personalised stem cell therapeutic intervention ever closer. Inevitably, with such rapid development, it is not possible to cover everything in a single collection of work. Instead, we hope that this book will provide a representative and informative glimpse into the world of stem cell biology as the field stands in 2011, and will be of interest to inquisitive lay readers and students, as well as academic researchers. Stem cell research has historically relied on materials derived from embryos, often human. Consequently, many ethical issues have been raised that require sensitive and balanced handling by researchers and governments alike. In some countries stem cell research was all but blocked; however, the rules of the game are changing. Now the pioneeri
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