Nutritional Elements and Clinical Biochemistry
The important role that the nutritional status exerts in determining the course of life from birth to death in the human being and especially its impact in disease states is only par tially appreciated at this time. Nutritional deficiencies are usually c
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Clinical Biochemistry
Nutritional Elements and
Clinical Biochemistry Edited by
Marge A. Brewster Departments of Pathology, Biochemistry, and Pediatrics, University of Arkansas for Medical Sciences and Metabolic Laboratory, Arkansas Children's Hospital Little Rock, Arkansas
and
Herbert K. Naito Department of Biochemistry, Division of Laboratory Medicine, Department of A therosclerosis and Thrombosis Research, Division of Research, Cleveland Clinic Foundation and Department of Chemistry, Cleveland State University, Cleveland, Ohio
PLENUM PRESS · NEW YORK AND LONDON
Library of Congress Cataloging in Publication Data Main entry under title: Nutritional elements and clinical biochemistry. "Proceedings of the third annual meeting of the National Academy of Clinical Biochemistry, held in New Orleans, Louisiana, July 13-14, 1979." Includes bibliographies and index. 1. Nutrition disorders-Congresses. 2. Biological chemistry-Congresses. 3. NutritionCongresses. I. Brewster, Marge A. II. Naito, Herbert K. III. National Academy of Clinical Biochemistry (U.S.) RC620.N86 616.3'9 80-21136 ISBN-13:978-1-4613-3170-4 e-ISBN-13:978-1-4613-3168-1 DOl: 10.1007/978-1-4613-3168-1
Proceedings of the Third Annual Meeting of the National Academy of Clinical Biochemistry, held in New Orleans, Louisiana, July 13-14, 1979
© 1980 Plenum Press, New York
Softcover reprint of the hardcover 1st edition 1980 A Division of Plenum Publishing Corporation 227 West 17th Street New York, N.Y. 10011 All rights reserved No part of this book may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise, without written permission from the publisher
Preparation of this volume has been an effort of the National Academy of Clinical Biochemistry, derived in part from the program of the third annual meeting, held in New Orleans, Louisiana, July 13-14, 1979.
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FOREWORD
The important role that the nutritional status exerts in determining the course of life from birth to death in the human being and especially its impact in disease states is only partially appreciated at this time. Nutritional deficiencies are usually considered to be major problems only in under-privileged or developing populations, except for those occurring in specific diseases. This attitude is incorrect as indicated by reports of Bestrian et al (1974, 1976) and Merritt and Suskin (1979) and others who found evidence of nutritional depletion in as much as 50% of the patients in varied groups of hospitalized patients in the United States. Other studies, some of which are included in this book, emphasized the existence of deficiencies of certain specific nutrients. Despite evidence of nutritional deficiencies occurring more frequently than previously appreciated, there is no well established protocol of laboratory studies that the clinical chemist or scientist should provide to help the physician detect lack of essential nutrients before extensive and possibly irreparable da
