Biochemistry and Cell Biology of Ageing: Part II Clinical Science

In recent years, volumes of the long-established Springer Subcellular Biochemistry series have shown great diversity of content, thus interesting biochemical topics, enthusiastically edited in all cases, have been readily accommodated.This new volume of t

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J. Robin Harris Viktor I. Korolchuk Editors

Biochemistry and Cell Biology of Ageing: Part II Clinical Science

Subcellular Biochemistry Volume 91

Series editor J. Robin Harris, Institute of Zoology, University of Mainz, Mainz, Germany

More information about this series at http://www.springer.com/series/6515

J. Robin Harris  •  Viktor I. Korolchuk Editors

Biochemistry and Cell Biology of Ageing: Part II Clinical Science

Editors J. Robin Harris Institute of Zoology University of Mainz Mainz, Germany

Viktor I. Korolchuk Newcastle University Newcastle upon Tyne, UK

ISSN 0306-0225 Subcellular Biochemistry ISBN 978-981-13-3680-5    ISBN 978-981-13-3681-2 (eBook) https://doi.org/10.1007/978-981-13-3681-2 Library of Congress Control Number: 2018965214 © Springer Nature Singapore Pte Ltd. 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore

Foreword

Never has it been more important or timely for new volumes on the science of ageing to be produced. Around the world, continuing gains in life expectancy coupled with declining fertility rates in many countries are producing profound shifts in demographic profiles. A growing fraction of the population is living to advanced old age, bringing with it increased prevalence of a wide range of age-related chronic diseases. Whereas it was once thought that ageing was something that just happened and that was relatively low on the priority list for research, recent decades have seen exciting advances in probing the complex mechanisms through which the ageing process develops. We have come a long way from the days when it was simply assumed there was some internal biological clock that would allow us an allotted span of “