Obesity suppresses circulating level and function of endothelial progenitor cells and heart function
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RESEARCH
Open Access
Obesity suppresses circulating level and function of endothelial progenitor cells and heart function Tzu-Hsien Tsai1†, Han-Tan Chai1†, Cheuk-Kwan Sun2, Chia-Hung Yen3, Steve Leu4, Yung-Lung Chen1, Sheng-Ying Chung1, Sheung-Fat Ko5, Hsueh-Wen Chang6†, Chiung-Jen Wu1 and Hon-Kan Yip1,7*†
Abstract Background and aim: This study tested the hypothesis that obesity suppresses circulating number as well as the function of endothelial progenitor cells (EPCs) and left ventricular ejection fraction (LVEF). Methods: High fat diet (45 Kcal% fat) was given to 8-week-old C57BL/6 J mice (n = 8) for 20 weeks to induce obesity (group 1). Another age-matched group (n = 8) were fed with control diet for 20 weeks as controls (group 2). The animals were sacrificed at the end of 20 weeks after obesity induction. Results: By the end of study period, the heart weight, body weight, abdominal fat weight, serum levels of total cholesterol and fasting blood sugar were remarkably higher in group 1 than in group 2 (all p
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