Oncocytic carcinoma of parotid gland: a case report with clinical, immunohistochemical and ultrastructural features
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Case report
Oncocytic carcinoma of parotid gland: a case report with clinical, immunohistochemical and ultrastructural features Giovanna Giordano*1, Marzio Gabrielli1, Letizia Gnetti1 and Teore Ferri2 Address: 1Department of Pathology and Medicine Laboratory, Section of Pathology, Parma University, Italy and 2Department of Otolaryngology, Parma University, Italy Email: Giovanna Giordano* - [email protected]; Marzio Gabrielli - [email protected]; Letizia Gnetti - [email protected]; Teore Ferri - [email protected] * Corresponding author
Published: 21 August 2006 World Journal of Surgical Oncology 2006, 4:54
doi:10.1186/1477-7819-4-54
Received: 13 March 2006 Accepted: 21 August 2006
This article is available from: http://www.wjso.com/content/4/1/54 © 2006 Giordano et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract Background: Oncocytic carcinoma is an extremely rare neoplasm of the salivary glands. We report a case of oncocytic carcinoma arising in a parotid gland in a 66-year-old female. Method: An excisional biopsy of the parotid tumor was performed. The specimen was submitted for histology and after fixation in formalin solution and inclusion in paraffin, 3–5 µm sections were stained with hematoxylin and eosin for conventional evaluation and Periodic acid Schiff stain. Immunohistochemical studies were performed using antibodies against mitochondrial antigen, keratin, S-100, alpha-actin, vimentin, alpha-1-antichymotrypsin as well as an ultrastructural analysis was performed. Results: Frozen sections revealed an infiltrative growth pattern and the diagnosis of a malignant epithelial lesion was made. Permanent sections stained with haematoxylin and eosin revealed a neoplasm that had replaced a wide area of the parotid gland and had invaded subcutaneous adipose tissue. Perineural invasion was evident, but vascular invasion was not found. Neoplastic elements were large, round or polyhedral cells and were arranged in solid sheets, islands and cords. The cytoplasm was abundant, eosinophilic and finely granular. The nuclei were large and located centrally or peripherally. The nucleoli were distinct and large. Periodic acid Schiff stain demonstrated a granular cytoplasm. Immunohistochemistry demonstrated mithochondrial antigen, keratin, and chymotrypsin immunoreactivity in the neoplastic cells. Ultrastructural analysis revealed numerous mitochondria packed into the cytoplasm of the neoplastic cells. Thus, the final diagnosis was that of oncocytic carcinoma of parotid gland. Conclusion: This neoplasm shows clinical, microscopical, histological and ultrastructural features of oncocytic carcinoma and this must be considered in the differential diagnosis of other proliferations in the parotid gland with abundant granular cytoplas
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